Virally induced liver cancer usually evolves over long periods of time in the context of a
strongly oxidative microenvironment, characterized by chronic liver inflammation and …

Hepatocellular carcinoma (HCC) is the most common primary malignant tumor that accounts
for~ 80% of all liver cancer cases worldwide. It is a multifactorial disease caused by a variety …

Aims The first-line treatment for advanced hepatocellular carcinoma (HCC) is the
multikinase inhibitor sorafenib (SOR). Sofafenib resistance is linked to protein kinase …

Long term hepatitis B virus (HBV) infection is a major risk factor in pathogenesis of chronic
liver diseases, including hepatocellular carcinoma (HCC). The HBV encoded proteins …

Oxidative stress (OS) is the imbalance between oxidant and antioxidant molecules, in favor
of oxidants, that causes aging and disease. Many studies have been published that …

The changes in and relationship between oxidative stress and the glutathione (GSH)
antioxidant system in the plasma and tissues of patients with hepatocellular carcinoma …

During inflammatory processes, immunocompetent cells are exposed to substantial amounts
of free radicals and toxic compounds. Glutathione is a cysteine-containing tripeptide that is …

NF-E2-related factor 2 (NRF2) is a basic leucine zipper transcription factor, a master
regulator of redox homeostasis regulating a variety of genes for antioxidant and …

The imbalance of high oxidative stress and low antioxidant capacities is thought to be a
significant cause of the development and progression of hepatocellular carcinoma (HCC) …

Hepatitis B virus (HBV) infection promotes reactive oxygen species production while
paradoxically inducing the expression of antioxidant enzymes. HBV-induced disorders of …