The initiation of eukaryotic DNA replication
A Costa, JFX Diffley - Annual review of biochemistry, 2022 - annualreviews.org
DNA replication in eukaryotic cells initiates from large numbers of sites called replication
origins. Initiation of replication from these origins must be tightly controlled to ensure the …
origins. Initiation of replication from these origins must be tightly controlled to ensure the …
Shaping human telomeres: from shelterin and CST complexes to telomeric chromatin organization
The regulation of telomere length in mammals is crucial for chromosome end-capping and
thus for maintaining genome stability and cellular lifespan. This process requires …
thus for maintaining genome stability and cellular lifespan. This process requires …
Structure of a human replisome shows the organisation and interactions of a DNA replication machine
ML Jones, Y Baris, MRG Taylor, JTP Yeeles - The EMBO journal, 2021 - embopress.org
The human replisome is an elaborate arrangement of molecular machines responsible for
accurate chromosome replication. At its heart is the CDC45‐MCM‐GINS (CMG) helicase …
accurate chromosome replication. At its heart is the CDC45‐MCM‐GINS (CMG) helicase …
[HTML][HTML] Cryo-EM structure of the fork protection complex bound to CMG at a replication fork
The eukaryotic replisome, organized around the Cdc45-MCM-GINS (CMG) helicase,
orchestrates chromosome replication. Multiple factors associate directly with CMG, including …
orchestrates chromosome replication. Multiple factors associate directly with CMG, including …
[HTML][HTML] Structure, dynamics and function of the 26S proteasome
Y Mao - Macromolecular protein complexes III: structure and …, 2021 - Springer
The 26S proteasome is the most complex ATP-dependent protease machinery, of~ 2.5 MDa
mass, ubiquitously found in all eukaryotes. It selectively degrades ubiquitin-conjugated …
mass, ubiquitously found in all eukaryotes. It selectively degrades ubiquitin-conjugated …
Single-molecule analysis and engineering of DNA motors
Molecular motors are diverse enzymes that transduce chemical energy into mechanical
work and, in doing so, perform critical cellular functions such as DNA replication and …
work and, in doing so, perform critical cellular functions such as DNA replication and …
Mechanism of eukaryotic origin unwinding is a dual helicase DNA shearing process
LD Langston, RE Georgescu… - Proceedings of the …, 2023 - National Acad Sciences
DNA replication in all cells begins with the melting of base pairs at the duplex origin to allow
access to single-stranded DNA templates which are replicated by DNA polymerases. In …
access to single-stranded DNA templates which are replicated by DNA polymerases. In …
[PDF][PDF] Proteome expansion in the Potyviridae evolutionary radiation
Potyviridae, the largest family of known RNA viruses (realm Riboviria), belongs to the
picorna-like supergroup and has important agricultural and ecological impacts. Potyvirid …
picorna-like supergroup and has important agricultural and ecological impacts. Potyvirid …
[HTML][HTML] Structure of the polymerase ε holoenzyme and atomic model of the leading strand replisome
Z Yuan, R Georgescu, GD Schauer… - Nature …, 2020 - nature.com
The eukaryotic leading strand DNA polymerase (Pol) ε contains 4 subunits, Pol2, Dpb2,
Dpb3 and Dpb4. Pol2 is a fusion of two B-family Pols; the N-terminal Pol module is catalytic …
Dpb3 and Dpb4. Pol2 is a fusion of two B-family Pols; the N-terminal Pol module is catalytic …
[HTML][HTML] Molecular basis for ATP-hydrolysis-driven DNA translocation by the CMG helicase of the eukaryotic replisome
P Eickhoff, HB Kose, F Martino, T Petojevic, FA Ali… - Cell reports, 2019 - cell.com
In the eukaryotic replisome, DNA unwinding by the Cdc45-MCM-Go-Ichi-Ni-San
(GINS)(CMG) helicase requires a hexameric ring-shaped ATPase named minichromosome …
(GINS)(CMG) helicase requires a hexameric ring-shaped ATPase named minichromosome …