The cornea is a specialized, transparent, avascular, immune-privileged, and heavily
innervated tissue that affords 2/3rd of refraction to the eye. Ocular injuries, infections, and …

The corneal stroma plays several pivotal roles within the eye. Optically, it is the main
refracting lens and thus has to combine almost perfect transmission of visible light with …

Corneal damage forms scar tissue and manifests as permanent corneal opacity, which is the
main cause of visual impairment caused by corneal diseases. To treat these diseases …

In the past decade, novel lamellar keratoplasty techniques such as Deep Anterior Lamellar
Keratoplasty (DALK) for anterior keratoplasty and Descemet stripping automated endothelial …

No other tissue in the body depends more on the composition and organization of the
extracellular matrix (ECM) for normal structure and function than the corneal stroma. The …

Myofibroblasts are activated in response to tissue injury with the primary task to repair lost or
damaged extracellular matrix. Enhanced collagen secretion and subsequent contraction …

The corneal wound healing response is typically initiated by injuries to the epithelium and/or
endothelium that may also involve the stroma. However, it can also be triggered by immune …

The microenvironments of tissues or organs are complex architectures comprised of
structural proteins including collagen. Particularly, the cornea is organized in a lattice pattern …

Redox homeostasis is a delicate balancing act of maintaining appropriate levels of
antioxidant defense mechanisms and reactive oxidizing oxygen and nitrogen species. Any …

Neural crest (NC) cells are a migratory cell population synonymous with vertebrate
evolution. They generate a wide variety of cell and tissue types during embryonic and adult …