Tuberculosis (TB), caused by respiratory infection with Mycobacterium tuberculosis, remains
a major global health threat. The only licensed TB vaccine, the one-hundred-year-old Bacille …

Human cytomegalovirus (HCMV) infection, the most common cause of congenital disease
globally, affecting an estimated 1 million newborns annually, can result in lifelong sequelae …

Viral vectors can generate high levels of recombinant protein expression providing the basis
for modern vaccine development. A large number of different viral vector expression systems …

Highlights•Human cytomegalovirus (HCMV) infection and HCMV-seropositivity have an age-
dependent impact on health and disease.•HCMV is associated with adverse health …

Vaccination has had great success in combating diseases, especially infectious diseases.
However, traditional vaccination strategies are ineffective for several life-threatening …

Non-human primate (NHP) models are important for vaccine development and also
contribute to HIV cure research. Although none of the animal models are perfect, NHPs …

Viral vector vaccine represents one of the important research directions of novel vaccines.
Viral vectors can efficiently deliver foreign genes and drive robust transgene expression in …

The different technology platforms used to make poultry vaccines are reviewed. Vaccines
based on classical technologies are either live attenuated or inactivated vaccines. Genetic …

An effective vaccine for combination antiretroviral therapy (cART)-free virologic control of
HIV-1 by enhancing antigen-specific effector-memory CD8+ T lymphocytes could be useful …

HIV-1 remains a major public health issue worldwide in spite of efficacious antiviral
therapies, but with no cure or preventive vaccine. The latter has been very challenging, as …