Synthetic and medicinal perspective of antileishmanial agents: an overview

S Pawar, MK Kumawat, M Kundu, K Kumar - Journal of Molecular Structure, 2023 - Elsevier
Leishmaniasis is one of the most common neglected tropical diseases (NTD), and is
originated in over 98 countries, affecting about 12 million people every year, which is …

Transcriptional profiling of canine osteosarcoma identifies prognostic gene expression signatures with translational value for humans

JD Mannheimer, G Tawa, D Gerhold, J Braisted… - Communications …, 2023 - nature.com
Canine osteosarcoma is increasingly recognized as an informative model for human
osteosarcoma. Here we show in one of the largest clinically annotated canine osteosarcoma …

Comparative transcriptomic analysis of long noncoding RNAs in Leishmania-infected human macrophages

JCR Fernandes, ANA Gonçalves… - Frontiers in …, 2023 - frontiersin.org
It is well established that infection with Leishmania alters the host cell's transcriptome. Since
mammalian cells have multiple mechanisms to control gene expression, different molecules …

[HTML][HTML] Exploring the impact of epidemiological and clinical factors on the progression of canine leishmaniosis by statistical and whole genome analyses: from breed …

CR Sanz, J Sarquis, MÁ Daza, G Miró - International Journal for …, 2024 - Elsevier
Canine leishmaniosis (CanL), caused by Leishmania infantum, is a complex disease of
growing importance in Europe. Clinical manifestations result from the down-modulation of …

The host micro-RNA cfa-miR-346 is induced in canine leishmaniasis

G Buffi, A Diotallevi, M Ceccarelli, F Bruno… - BMC Veterinary …, 2022 - Springer
Background Leishmaniases are a group of anthropo-zoonotic parasitic diseases caused by
a protozoan of the Leishmania genus, affecting both humans and other vertebrates …

Leishmania infantum infection modulates messenger RNA, microRNA and long non-coding RNA expression in human neutrophils in vitro

NF Scaramele, JA Troiano, JS Felix… - PLOS Neglected …, 2024 - journals.plos.org
In the Americas, L. infantum (syn. chagasi) is the main cause of human visceral
leishmaniasis. The role of neutrophils as part of the innate response to Leishmania spp …

Immunological and genomic characterization of Ibizan Hound dogs in an endemic Leishmania infantum region

L Álvarez, PJ Marín-García, L Llobat - Parasites & Vectors, 2022 - Springer
Abstract Background The Ibizan Hound is a canine breed native to the Mediterranean
region, where leishmaniosis is an endemic zoonosis. Several studies indicate low …

[HTML][HTML] Immunological profile of two canine breeds in an endemic region of Leishmania infantum

M Macià, PJ Marín-García, AE Ahuir-Baraja… - … : Regional Studies and …, 2023 - Elsevier
Visceral leishmaniosis is the one of the most important protozoal zoonoses in Europe, and it
is caused by Leishmania infantum, an intracellular protozoan parasite. The disease is …

The role of atypical MAP kinase 4 in the host interaction with Cryptosporidium parvum

N Watanabe, H Bando, F Murakoshi, R Sakurai… - Scientific Reports, 2023 - nature.com
Cryptosporidium parvum is an apicomplexan parasite that causes severe zoonotic diarrhea
in humans and calves. Since there are no effective treatments or vaccines for infants or …

Dissection of the macrophage response towards infection by the Leishmania-viral endosymbiont duo and dynamics of the type I interferon response

A Bekkar, N Isorce, T Snäkä, S Claudinot… - Frontiers in cellular …, 2022 - frontiersin.org
Leishmania RNA virus 1 (LRV1) is a double-stranded RNA virus found in some strains of the
human protozoan parasite Leishmania, the causative agent of leishmaniasis, a neglected …