Microbial secondary metabolites (MSMs) have played and continue to play a highly
significant role in the drug discovery and development process. Genetically, MSM chemical …

Fungi have the capability to produce a tremendous number of so-called secondary
metabolites, which possess a multitude of functions, eg, communication signals during …

Dereplication represents a key step for rapidly identifying known secondary metabolites in
complex biological matrices. In this context, liquid-chromatography coupled to high …

Cyclic depsipeptides (CDPs) are cyclopeptides in which amide groups are replaced by
corresponding lactone bonds due to the presence of a hydroxylated carboxylic acid in the …

Genomic analysis has demonstrated that many fungi possess essential gene clusters for the
production of previously unobserved secondary metabolites; however, these genes are …

Covering: 2014 up to the third quarter of 2019 Entomopathogens constitute a unique,
specialized trophic subgroup of fungi, most of whose members belong to the order …

Polyketides 1–6 were produced by a one strain-many compounds (OSMAC) approach using
the endophytic fungus Dothideomycete sp. CRI7 as a producer. Metabolite production of the …

Elastases are a broad group of enzymes involved in the lysis of elastin, the main component
of elastic fibres. They are produced and released in the human body, mainly by neutrophils …

Fungal secondary metabolites are small molecules that exhibit diverse biological activities
exploited in medicine, industry and agriculture. Their biosynthesis is governed by co …

There have been significant advances in the flexibility and power of in vitro cell-free
translation systems. The increasing ability to incorporate noncanonical amino acids and …