[HTML][HTML] Exosomal miRNAs in central nervous system diseases: biomarkers, pathological mediators, protective factors and therapeutic agents
Exosomes are small bilipid layer-enclosed extracellular vesicles that can be found in tissues
and biological fluids. As a key cell-to-cell and distant communication mediator, exosomes …
and biological fluids. As a key cell-to-cell and distant communication mediator, exosomes …
MicroRNAs in epilepsy: pathophysiology and clinical utility
Background Temporal lobe epilepsy is a common and frequently intractable seizure
disorder. Its pathogenesis is thought to involve large-scale alterations to the expression of …
disorder. Its pathogenesis is thought to involve large-scale alterations to the expression of …
[HTML][HTML] Restoring miR-132 expression rescues adult hippocampal neurogenesis and memory deficits in Alzheimer's disease
H Walgrave, S Balusu, S Snoeck, EV Eynden… - Cell Stem Cell, 2021 - cell.com
Neural stem cells residing in the hippocampal neurogenic niche sustain lifelong
neurogenesis in the adult brain. Adult hippocampal neurogenesis (AHN) is functionally …
neurogenesis in the adult brain. Adult hippocampal neurogenesis (AHN) is functionally …
Silencing microRNA-134 produces neuroprotective and prolonged seizure-suppressive effects
Temporal lobe epilepsy is a common, chronic neurological disorder characterized by
recurrent spontaneous seizures. MicroRNAs (miRNAs) are small, noncoding RNAs that …
recurrent spontaneous seizures. MicroRNAs (miRNAs) are small, noncoding RNAs that …
MicroRNAs as regulators of brain function and targets for treatment of epilepsy
GP Brennan, DC Henshall - Nature Reviews Neurology, 2020 - nature.com
Seizures result from hypersynchronous, abnormal firing of neuronal populations and are the
primary clinical symptom of the epilepsies. Brain tissue from animal models and patients …
primary clinical symptom of the epilepsies. Brain tissue from animal models and patients …
miR-212/132 expression and functions: within and beyond the neuronal compartment
A Wanet, A Tacheny, T Arnould… - Nucleic acids …, 2012 - academic.oup.com
During the last two decades, microRNAs (miRNAs) emerged as critical regulators of gene
expression. By modulating the expression of numerous target mRNAs mainly at the post …
expression. By modulating the expression of numerous target mRNAs mainly at the post …
MicroRNAs in neurodegenerative diseases
MicroRNAs are small noncoding RNAs that regulate gene expression at the
posttranscriptional level in a sequence-specific manner. After their discovery in 1993 …
posttranscriptional level in a sequence-specific manner. After their discovery in 1993 …
[HTML][HTML] MicroRNA expression profile of the hippocampus in a rat model of temporal lobe epilepsy and miR-34a-targeted neuroprotection against hippocampal …
K Hu, YY Xie, C Zhang, DS Ouyang, HY Long… - BMC neuroscience, 2012 - Springer
Background The expression pattern and function of miRNAs in the rat model of temporal
lobe epilepsy have not been well defined. Profiling miRNA expression in the rat model of …
lobe epilepsy have not been well defined. Profiling miRNA expression in the rat model of …
Hippocampal subregion-specific microRNA expression during epileptogenesis in experimental temporal lobe epilepsy
JA Gorter, A Iyer, I White, A Colzi, EA van Vliet… - Neurobiology of …, 2014 - Elsevier
Since aberrant miRNA expression has been implicated in numerous brain diseases, we
studied miRNA expression and miRNA regulation of important signaling pathways during …
studied miRNA expression and miRNA regulation of important signaling pathways during …
miR‐132 loss de‐represses ITPKB and aggravates amyloid and TAU pathology in Alzheimer's brain
E Salta, A Sierksma, E Vanden Eynden… - EMBO molecular …, 2016 - embopress.org
Abstract microRNA‐132 (miR‐132) is involved in prosurvival, anti‐inflammatory and memory‐
promoting functions in the nervous system and has been found consistently downregulated …
promoting functions in the nervous system and has been found consistently downregulated …