Calcitonin gene-related peptide (CGRP) is a neuropeptide with diverse physiological
functions. Its two isoforms (α and β) are widely expressed throughout the body in sensory …

Amylin is a pancreatic β-cell hormone that produces effects in several different organ
systems. Here, we review the literature in rodents and in humans on amylin research since …

G protein-coupled receptors (GPCRs) are known to interact with several other classes of
integral membrane proteins that modulate their biology and pharmacology. However, the …

Amylin receptors (AMYRs) are heterodimers of the calcitonin (CT) receptor (CTR) and one of
three receptor activity–modifying proteins (RAMPs), AMY1R, AMY2R, and AMY3R. Selective …

It is now recognized that G protein–coupled receptors (GPCRs), once considered largely
independent functional units, have a far more diverse molecular architecture. Receptor …

G protein-coupled receptors (GPCRs) are a key drug target class. They account for over one-
third of current pharmaceuticals, and both drugs that inhibit and promote receptor function …

Calcitonin gene-related peptide (CGRP) plays a pivotal role in migraine, activating its
cognate receptor to initiate intracellular signalling. This atypical receptor comprises a distinct …

Hypertension is still presently the number one “silent killer” in the Western World, and a
major risk factor for the development of secondary diseases contributing to cardiovascular …

Class BG protein-coupled receptors (GPCRs) respond to paracrine or endocrine peptide
hormones involved in control of bone homeostasis, glucose regulation, satiety, and gastro …

Amylin is an important, but poorly understood, 37 amino acid glucoregulatory hormone with
great potential to target metabolic diseases. A working example that the amylin system is …