The current review deals with the use of ring expansion reactions for the synthesis of sulfur-
containing heterocycles. Ring enlargement offers by far a convenient method for the …

Aryl and heteroaryl rings are omnipresent in small molecule drugs, and examples bearing
multiple substitutions at benzylic positions are ubiquitous across a range of pharmaceutical …

1-Aryl-1H-benzotriazoles and-1H-indazoles were synthesized, and their deproto-metallation
using the base prepared by mixing LiTMP with ZnCl2· TMEDA (1/3 equiv.) was studied. In …

Directed lithiation of substituted aromatics and heterocycles containing a directing
metalating group with alkyllithium in anhydrous tetrahydrofuran or diethyl ether at low …

Lithiation of N-(pyridin-3-ylmethyl) pivalamide, tert-butyl N-(pyridin-3-ylmethyl) carbamate,
and N, N-dimethyl-N′-(pyridin-3-ylmethyl) urea with tert-butyllithium (3 equiv) in anhydrous …

Background: A series of novel substituted 3-(thiophen-2-yl) pyrazoles was synthesized
efficiently and in high yields using simple and convenient procedures starting from 1-phenyl …

Reactions of phenyl isothiocyanate with several active methylene compounds 1 (3-oxo-3-
phenylpropanenitrile, ethyl 2-cyanoacetate, pentane-2, 4-dione and ethyl acetoacetate) and …

Ureas, pivalamides, and carbamates are widely used as directing metalation groups (DMGs)
due to their good directing ability, low cost, ease of access, and ease of removal. Lithiation of …

In the title compound, C11H16N2O, the dihedral angle between the mean plane of the 4-
methypyridine group and the plane of the amide link is 16.7 (1)°, and there is a short …

In the title compound, C10H14N2O, the pyridine ring is inclined to the mean plane of the
amide moiety [N—C (= O) C] by 17.60 (8)°. There is an intramolecular C—H⋯ O hydrogen …