The hexosamine biosynthetic pathway (HBP) is a glucose metabolism pathway that results
in the synthesis of a nucleotide sugar UDP-GlcNAc, which is subsequently used for the post …

O-linked β-dN-acetylglucosamine (O-GlcNAc) is an important post-translational modification
of serine or threonine residues on thousands of proteins in the nucleus and cytoplasm of all …

Advanced colorectal cancer (CRC) is one of the deadliest cancers, and the 5-year survival
rate of patients with metastasis is extremely low. The epithelial–mesenchymal transition …

O-linked β-DN-acetylglucosamine (O-GlcNAc), as a posttranslational modification (PTM), is
a reversible reaction that attaches β-N-GlcNAc to Ser/Thr residues on specific proteins by O …

Modification of nucleocytoplasmic proteins with O-GlcNAc regulates a wide variety of cellular
processes and has been linked to human diseases. The enzymes O-GlcNAc transferase …

Colorectal cancer (CRC) is the fourth leading cause of cancer-related deaths in the world.
Drug resistance of tumour cells remains the main challenge toward curative treatments …

Tumors frequently exhibit aberrant glycosylation, which can impact cancer progression and
therapeutic responses. The hexosamine biosynthesis pathway (HBP) produces uridine …

Fatty acid synthase (FASN) participates in many fundamental biological processes,
including energy storage and signal transduction, and is overexpressed in many cancer …

Alteration of O-GlcNAcylation, a dynamic posttranslational modification, is associated with
tumorigenesis and tumor progression. Its role in chemotherapy response is poorly …

Colorectal cancer (CRC) is one of the main causes of cancer death in the world. Post-
translational modifications (PTMs) have been extensively studied in malignancies due to its …