[HTML][HTML] Attention-deficit hyperactivity disorder in adults: a systematic review and meta-analysis of genetic, pharmacogenetic and biochemical studies

C Bonvicini, SV Faraone, C Scassellati - Molecular psychiatry, 2016 - nature.com
The adult form of attention-deficit/hyperactivity disorder has a prevalence of up to 5% and is
the most severe long-term outcome of this common disorder. Family studies in clinical …

Genetic risk factors and gene–environment interactions in adult and childhood attention-deficit/hyperactivity disorder

VS Palladino, R McNeill, A Reif… - Psychiatric …, 2019 - journals.lww.com
Attention-deficit/hyperactivity disorder (ADHD) is a common and highly heritable
neurodevelopmental disorder. In recent years, genetic studies have revealed several risk …

Does serotonin deficit mediate susceptibility to ADHD?

E Banerjee, K Nandagopal - Neurochemistry international, 2015 - Elsevier
The onset of attention-deficit-hyperactivity-disorder (ADHD) in childhood is characterized by
developmentally inappropriate levels of hyperactivity, impulsivity and inattention. A chronic …

TPH2 polymorphisms across the spectrum of psychiatric morbidity: A systematic review and meta-analysis

KW Ottenhof, M Sild, ML Lévesque, HG Ruhé… - … & Biobehavioral Reviews, 2018 - Elsevier
Abstract Tryptophan hydroxylase 2 (TPH2) is the rate-limiting enzyme in brain serotonin
synthesis. The TPH2 gene has frequently been investigated in relation to psychiatric …

SNARE complex in developmental psychiatry: neurotransmitter exocytosis and beyond

RB Cupertino, DB Kappel, CE Bandeira… - Journal of Neural …, 2016 - Springer
Multiple biological processes throughout development require intracellular vesicular
trafficking, where the SNARE (soluble N-ethylmaleimide-sensitive factor (NSF) attachment …

COMT val158met moderation of dopaminergic drug effects on cognitive function: a critical review

JP Schacht - The pharmacogenomics journal, 2016 - nature.com
The relationship between dopamine (DA) tone in the prefrontal cortex (PFC) and PFC-
dependent cognitive functions (for example, working memory, selective attention, executive …

[HTML][HTML] Genetics in the ADHD clinic: how can genetic testing support the current clinical practice?

L Balogh, AJ Pulay, JM Réthelyi - Frontiers in Psychology, 2022 - frontiersin.org
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder with a
childhood prevalence of 5%. In about two-thirds of the cases, ADHD symptoms persist into …

ADHD pharmacogenetics across the life cycle: new findings and perspectives

EM Bruxel, GC Akutagava‐Martins… - American Journal of …, 2014 - Wiley Online Library
Attention‐deficit/hyperactivity disorder (ADHD) is a complex and heterogeneous disorder,
affecting individuals across the life cycle. Although its etiology is not yet completely …

PharmGKB summary: methylphenidate pathway, pharmacokinetics/pharmacodynamics

T Stevens, K Sangkuhl, JT Brown… - Pharmacogenetics …, 2019 - journals.lww.com
Overview Methylphenidate (MPH) is a central nervous system stimulant primarily used for
the treatment of attention deficit hyperactivity disorder (ADHD). MPH works by preventing the …

Methylphenidate in adults with attention deficit hyperactivity disorder and substance use disorders

N Simon, B Rolland, L Karila - Current pharmaceutical design, 2015 - ingentaconnect.com
Attention-Deficit/Hyperactivity Disorder (ADHD) is a neurodevelopment disorder occurring
during childhood. However, ADHD persists into adulthood in 45.7% of cases. The global …