Origin, structure, and composition of the spider major ampullate silk fiber revealed by genomics, proteomics, and single-cell and spatial transcriptomics
S Sonavane, S Hassan, U Chatterjee, L Soler… - Science …, 2024 - science.org
Spiders produce nature's toughest fiber using renewable components at ambient
temperatures and with water as solvent, making it highly interesting to replicate for the …
temperatures and with water as solvent, making it highly interesting to replicate for the …
Disentangling the Web: An Interdisciplinary Review on the Potential and Feasibility of Spider Silk Bioproduction
G Guessous, L Blake, A Bui, Y Woo… - … Science & Engineering, 2024 - ACS Publications
The remarkable material properties of spider silk, such as its high toughness and tensile
strength combined with its low density, make it a highly sought-after material with myriad …
strength combined with its low density, make it a highly sought-after material with myriad …
Engineered Protein Hydrogels as Biomimetic Cellular Scaffolds
The biochemical and biophysical properties of the extracellular matrix (ECM) play a pivotal
role in regulating cellular behaviors such as proliferation, migration, and differentiation …
role in regulating cellular behaviors such as proliferation, migration, and differentiation …
Generative retrieval-augmented ontologic graph and multiagent strategies for interpretive large language model-based materials design
MJ Buehler - ACS Engineering Au, 2024 - ACS Publications
Transformer neural networks show promising capabilities, in particular for uses in materials
analysis, design, and manufacturing, including their capacity to work effectively with human …
analysis, design, and manufacturing, including their capacity to work effectively with human …
AtomAgents: Alloy design and discovery through physics-aware multi-modal multi-agent artificial intelligence
A Ghafarollahi, MJ Buehler - arXiv preprint arXiv:2407.10022, 2024 - arxiv.org
The design of alloys is a multi-scale problem that requires a holistic approach that involves
retrieving relevant knowledge, applying advanced computational methods, conducting …
retrieving relevant knowledge, applying advanced computational methods, conducting …
Cephalo: Multi‐Modal Vision‐Language Models for Bio‐Inspired Materials Analysis and Design
MJ Buehler - Advanced Functional Materials, 2024 - Wiley Online Library
Cephalo is presented as a series of multimodal vision large language models (V‐LLMs)
designed for materials science applications, integrating visual and linguistic data for …
designed for materials science applications, integrating visual and linguistic data for …
Adaptive CVgen: Leveraging reinforcement learning for advanced sampling in protein folding and chemical reactions
Enhanced sampling techniques have traditionally encountered two significant challenges:
identifying suitable reaction coordinates and addressing the exploration–exploitation …
identifying suitable reaction coordinates and addressing the exploration–exploitation …
[HTML][HTML] X-LoRA: Mixture of low-rank adapter experts, a flexible framework for large language models with applications in protein mechanics and molecular design
EL Buehler, MJ Buehler - APL Machine Learning, 2024 - pubs.aip.org
We report a mixture of expert strategy to create fine-tuned large language models using a
deep layer-wise token-level approach based on low-rank adaptation (LoRA). Starting with a …
deep layer-wise token-level approach based on low-rank adaptation (LoRA). Starting with a …
ProtAgents: protein discovery via large language model multi-agent collaborations combining physics and machine learning
A Ghafarollahi, MJ Buehler - Digital Discovery, 2024 - pubs.rsc.org
Designing de novo proteins beyond those found in nature holds significant promise for
advancements in both scientific and engineering applications. Current methodologies for …
advancements in both scientific and engineering applications. Current methodologies for …
Artificial Spider Silk Materials: From Molecular Design, Mesoscopic Assembly, to Macroscopic Performances
Spider silk is one of the strongest and toughest fibrous materials available in nature. Its
superior properties make it a good candidate for applications in various fields ranging from …
superior properties make it a good candidate for applications in various fields ranging from …