Current concepts in the pathogenesis of periodontitis: from symbiosis to dysbiosis
AA Abdulkareem, FB Al-Taweel… - Journal of Oral …, 2023 - Taylor & Francis
The primary etiological agent for the initiation and progression of periodontal disease is the
dental plaque biofilm which is an organized aggregation of microorganisms residing within a …
dental plaque biofilm which is an organized aggregation of microorganisms residing within a …
The oral microbiota: dynamic communities and host interactions
RJ Lamont, H Koo, G Hajishengallis - Nature reviews microbiology, 2018 - nature.com
The dynamic and polymicrobial oral microbiome is a direct precursor of diseases such as
dental caries and periodontitis, two of the most prevalent microbially induced disorders …
dental caries and periodontitis, two of the most prevalent microbially induced disorders …
Polymicrobial communities in periodontal disease: Their quasi‐organismal nature and dialogue with the host
G Hajishengallis, RJ Lamont - Periodontology 2000, 2021 - Wiley Online Library
In health, indigenous polymicrobial communities at mucosal surfaces maintain an ecological
balance via both inter‐microbial and host‐microbial interactions that promote their own and …
balance via both inter‐microbial and host‐microbial interactions that promote their own and …
Periodontitis: from microbial immune subversion to systemic inflammation
G Hajishengallis - Nature reviews immunology, 2015 - nature.com
Periodontitis is a dysbiotic inflammatory disease with an adverse impact on systemic health.
Recent studies have provided insights into the emergence and persistence of dysbiotic oral …
Recent studies have provided insights into the emergence and persistence of dysbiotic oral …
Role of Porphyromonas gingivalis in oral and orodigestive squamous cell carcinoma
RJ Lamont, ZR Fitzsimonds, H Wang… - Periodontology …, 2022 - Wiley Online Library
Oral and esophageal squamous cell carcinomas harbor a diverse microbiome that differs
compositionally from precancerous and healthy tissues. Though causality is yet to be …
compositionally from precancerous and healthy tissues. Though causality is yet to be …
Basic biology and role of interleukin‐17 in immunity and inflammation
C Zenobia, G Hajishengallis - Periodontology 2000, 2015 - Wiley Online Library
Interleukin‐17 (also known as interleukin‐17A) is a key cytokine that links T‐cell activation to
neutrophil mobilization and activation. As such, interleukin‐17 can mediate protective innate …
neutrophil mobilization and activation. As such, interleukin‐17 can mediate protective innate …
Polymicrobial synergy and dysbiosis in inflammatory disease
RJ Lamont, G Hajishengallis - Trends in molecular medicine, 2015 - cell.com
Uncontrolled inflammation of the periodontal area may arise when complex microbial
communities transition from a commensal to a pathogenic entity. Communication among …
communities transition from a commensal to a pathogenic entity. Communication among …
Immunomicrobial pathogenesis of periodontitis: keystones, pathobionts, and host response
G Hajishengallis - Trends in immunology, 2014 - cell.com
Recent studies have uncovered novel mechanisms underlying the breakdown of periodontal
host–microbe homeostasis, which can precipitate dysbiosis and periodontitis in susceptible …
host–microbe homeostasis, which can precipitate dysbiosis and periodontitis in susceptible …
Breaking bad: Manipulation of the host response by Porphyromonas gingivalis
G Hajishengallis, RJ Lamont - European journal of immunology, 2014 - Wiley Online Library
Recent metagenomic and mechanistic studies are consistent with a new model of
periodontal pathogenesis. This model proposes that periodontal disease is initiated by a …
periodontal pathogenesis. This model proposes that periodontal disease is initiated by a …
Neutrophil-derived chemokines on the road to immunity
C Tecchio, MA Cassatella - Seminars in immunology, 2016 - Elsevier
During recent years, it has become clear that polymorphonuclear neutrophils are remarkably
versatile cells, whose functions go far beyond phagocytosis and killing. In fact, besides …
versatile cells, whose functions go far beyond phagocytosis and killing. In fact, besides …