Review of Hair Cell Synapse Defects in Sensorineural Hearing... : Otology & Neurotology
Review of Hair Cell Synapse Defects in Sensorineural Hearing Impairment : Otology & …

Spontaneous electrical activity is a common feature of sensory systems during early
development. This sensory-independent neuronal activity has been implicated in promoting …

Cochlear inner hair cells (IHCs) release neurotransmitter onto afferent auditory nerve fibers
in response to sound stimulation. During early development, afferent synaptic transmission …

Neurons in the developing auditory system fire bursts of action potentials before the onset of
hearing. This spontaneous activity promotes the survival and maturation of auditory neurons …

Voltage-gated LTCCs (L-type Ca2+ channels) are established drug targets for the treatment
of cardiovascular diseases. LTCCs are also expressed outside the cardiovascular system. In …

CaV1. 3 channels comprise a vital subdivision of L-type Ca2+ channels: CaV1. 3 channels
mediate neurotransmitter release from auditory inner hair cells (IHCs), pancreatic insulin …

Multiple Ca 2+ channels confer diverse functions to hair cells of the auditory and vestibular
organs in the mammalian inner ear. We used gene-targeting technology to generate α 1D …

Outer hair cells (OHC) serve as electromechanical amplifiers that guarantee the unique
sensitivity and frequency selectivity of the mammalian cochlea. It is unknown whether the …

Within the Cav1 family of voltage-gated calcium channels, Cav1. 2 and Cav1. 3 channels
are the predominant subtypes in the brain. Whereas specific functions for each subtype were …

The molecular basis of high versus low frequency hearing loss and the differences in the
sensitivity of outer hair cells depending on their cochlear localization are currently not …