Genetics meets proteomics: perspectives for large population-based studies
Proteomic analysis of cells, tissues and body fluids has generated valuable insights into the
complex processes influencing human biology. Proteins represent intermediate phenotypes …
complex processes influencing human biology. Proteins represent intermediate phenotypes …
[HTML][HTML] Metabolic analysis as a driver for discovery, diagnosis, and therapy
RJ DeBerardinis, KR Keshari - Cell, 2022 - cell.com
Metabolic anomalies contribute to tissue dysfunction. Current metabolism research spans
from organelles to populations, and new technologies can accommodate investigation …
from organelles to populations, and new technologies can accommodate investigation …
Genomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases
Y Chen, T Lu, U Pettersson-Kymmer, ID Stewart… - Nature …, 2023 - nature.com
Metabolic processes can influence disease risk and provide therapeutic targets. By
conducting genome-wide association studies of 1,091 blood metabolites and 309 metabolite …
conducting genome-wide association studies of 1,091 blood metabolites and 309 metabolite …
[HTML][HTML] Influence of the microbiome, diet and genetics on inter-individual variation in the human plasma metabolome
The levels of the thousands of metabolites in the human plasma metabolome are strongly
influenced by an individual's genetics and the composition of their diet and gut microbiome …
influenced by an individual's genetics and the composition of their diet and gut microbiome …
A reference map of potential determinants for the human serum metabolome
The serum metabolome contains a plethora of biomarkers and causative agents of various
diseases, some of which are endogenously produced and some that have been taken up …
diseases, some of which are endogenously produced and some that have been taken up …
A laser-engraved wearable sensor for sensitive detection of uric acid and tyrosine in sweat
Wearable sweat sensors have the potential to provide continuous measurements of useful
biomarkers. However, current sensors cannot accurately detect low analyte concentrations …
biomarkers. However, current sensors cannot accurately detect low analyte concentrations …
[HTML][HTML] Genome-wide association studies of metabolites in Finnish men identify disease-relevant loci
Few studies have explored the impact of rare variants (minor allele frequency< 1%) on
highly heritable plasma metabolites identified in metabolomic screens. The Finnish …
highly heritable plasma metabolites identified in metabolomic screens. The Finnish …
Biofuel-powered soft electronic skin with multiplexed and wireless sensing for human-machine interfaces
Existing electronic skin (e-skin) sensing platforms are equipped to monitor physical
parameters using power from batteries or near-field communication. For e-skins to be …
parameters using power from batteries or near-field communication. For e-skins to be …
Genome-wide association analyses define pathogenic signaling pathways and prioritize drug targets for IgA nephropathy
IgA nephropathy (IgAN) is a progressive form of kidney disease defined by glomerular
deposition of IgA. Here we performed a genome-wide association study of 10,146 kidney …
deposition of IgA. Here we performed a genome-wide association study of 10,146 kidney …
Global kidney health 2017 and beyond: a roadmap for closing gaps in care, research, and policy
The global nephrology community recognises the need for a cohesive plan to address the
problem of chronic kidney disease (CKD). In July, 2016, the International Society of …
problem of chronic kidney disease (CKD). In July, 2016, the International Society of …