Importance Standard therapy for locally advanced rectal cancer includes concurrent
chemoradiotherapy followed by surgery and adjuvant chemotherapy (CRT plus A). An …

Colorectal cancer (CRC) is a public health problem. It is the third most common cancer in the
world, with nearly 1.8 million new cases diagnosed in 2018. The only curative treatment is …

The American Society of Colon and Rectal Surgeons (ASCRS) is dedicated to ensuring high-
quality patient care by advancing the science, prevention, and management of disorders …

Rectal cancer treatment has evolved during the past 40 years with the use of a standardized
surgical technique for tumour resection: total mesorectal excision. A dramatic reduction in …

Background Preoperative assessment of pathologic complete response (pCR) in locally
advanced rectal cancer (LARC) after neoadjuvant chemoradiotherapy (nCRT) is …

Background Watch and wait is a novel management strategy in patients with rectal cancer
who have a clinical complete response after neoadjuvant chemoradiotherapy. Surveillance …

PURPOSE In the multicenter, open-label, phase III FOWARC trial, modified infusional
fluorouracil, leucovorin, and oxaliplatin (mFOLFOX6) plus radiotherapy resulted in a higher …

Preoperative neoadjuvant chemoradiotherapy (nCRT) is a standard treatment for locally
advanced rectal cancer (LARC) patients, yet little is known about the mediators underlying …

Background Preoperative chemoradiotherapy (CRT) followed by total mesorectal excision is
widely accepted as the standard of care for high-risk rectal cancer. Adjuvant chemotherapy …

Background & Aims In accordance with guidelines, most patients with T1 colorectal cancers
(CRC) undergo surgical resection with lymph node dissection, despite the low incidence (∼ …