Vascular mineralization has recently emerged as a risk factor for cardiovascular morbidity
and mortality. Previously regarded as a passive end-stage process, vascular mineralization …

Pseudoxanthoma elasticum (PXE) is a genetic metabolic disease with autosomal recessive
inheritance caused by mutations in the ABCC6 gene. The lack of functional ABCC6 protein …

Purpose RAF inhibitors are effective against melanomas with BRAF V600E mutations but
may induce keratoacanthomas (KAs) and cutaneous squamous cell carcinomas (cSCCs) …

Spontaneous pathologic arterial calcifications in childhood can occur in generalized arterial
calcification of infancy (GACI) or in pseudoxanthoma elasticum (PXE). GACI is associated …

Artery calcification reflects an admixture of factors such as ectopic osteochondral
differentiation with primary host pathological conditions. We review how genetic factors, as …

Most members of the large ATP-binding cassette (ABC) gene family are transporters
involved in substrate translocation across biological membranes. In eukaryotes, ABC …

Pseudoxanthoma elasticum (PXE) is a systemic disorder affecting elastic tissues most
markedly in skin, retina, and blood vessels. It is caused by mutations in the ABCC6 gene …

Pseudoxantoma elasticum (PXE), also known as Groenblad-Strandberg syndrome, is a rare
heritable disease with an estimated prevalence of 1: 50,000 in the general population. PXE …

Pseudoxanthoma elasticum (PXE), a prototype of heritable multisystem disorders, is
characterised by pathologic mineralisation of connective tissues, with primary clinical …

Purpose: To stratify the literature on angioid streaks, from pathophysiology to treatment.
Methods: Review of the current literature. Results: Angioid streaks are crack-like …