[HTML][HTML] Noncoding RNA therapeutics—challenges and potential solutions
M Winkle, SM El-Daly, M Fabbri, GA Calin - Nature reviews Drug …, 2021 - nature.com
Therapeutic targeting of noncoding RNAs (ncRNAs), such as microRNAs (miRNAs) and
long noncoding RNAs (lncRNAs), represents an attractive approach for the treatment of …
long noncoding RNAs (lncRNAs), represents an attractive approach for the treatment of …
Recent advances in targeted delivery of non-coding RNA-based therapeutics for atherosclerosis
X Li, H Qi, W Cui, Z Wang, X Fu, T Li, H Ma, Y Yang… - Molecular Therapy, 2022 - cell.com
Cardiovascular disease (CVD) has overtaken infectious illnesses as the leading cause of
mortality and disability worldwide. The pathology that underpins CVD is atherosclerosis …
mortality and disability worldwide. The pathology that underpins CVD is atherosclerosis …
[HTML][HTML] MicroRNA-34a: the bad guy in age-related vascular diseases
A Raucci, F Macrì, S Castiglione, I Badi… - Cellular and Molecular …, 2021 - Springer
The age-related vasculature alteration is the prominent risk factor for vascular diseases
(VD), namely, atherosclerosis, abdominal aortic aneurysm, vascular calcification (VC) and …
(VD), namely, atherosclerosis, abdominal aortic aneurysm, vascular calcification (VC) and …
[HTML][HTML] Targeting the microRNA-34a as a novel therapeutic strategy for cardiovascular diseases
CC Hua, XM Liu, LR Liang, LF Wang… - Frontiers in …, 2022 - frontiersin.org
Cardiovascular diseases (CVDs) are still the main cause of morbidity and mortality
worldwide and include a group of disorders varying from vasculature, myocardium …
worldwide and include a group of disorders varying from vasculature, myocardium …
Perspectives of using microRNA-loaded nanocarriers for epigenetic reprogramming of drug resistant colorectal cancers
OA Sukocheva, J Liu, ME Neganova… - Seminars in Cancer …, 2022 - Elsevier
Epigenetic regulation by microRNAs (miRs) demonstrated a promising therapeutic potential
of these molecules to regulate genetic activity in different cancers, including colorectal …
of these molecules to regulate genetic activity in different cancers, including colorectal …
[HTML][HTML] The impact of non-coding RNAs on macrophage polarization
Macrophage polarization is a process through which macrophages attain unique functional
features as a response to certain stimuli from their niche. Lipopolysaccharide and Th1 …
features as a response to certain stimuli from their niche. Lipopolysaccharide and Th1 …
[HTML][HTML] Inhibiting mir-34a-5p regulates doxorubicin-induced autophagy disorder and alleviates myocardial pyroptosis by targeting Sirt3-AMPK pathway
Z Zhong, Y Gao, J Zhou, F Wang, P Zhang, S Hu… - Biomedicine & …, 2023 - Elsevier
Doxorubicin (DOX) is a commonly used chemotherapy drug widely applied in various
cancers such as breast cancer, leukemia, and sarcomas. However, its usage is limited by …
cancers such as breast cancer, leukemia, and sarcomas. However, its usage is limited by …
A review on ethnopharmacology, phytochemistry, pharmacology and potential uses of Portulaca oleracea L.
K Li, T Xia, Y Jiang, N Wang, L Lai, S Xu, X Yue… - Journal of …, 2023 - Elsevier
Ethnopharmacological relevance Portulaca oleracea L.(PO), popularly known as purslane,
has been documented in ethnopharmacology in various countries and regions. Traditional …
has been documented in ethnopharmacology in various countries and regions. Traditional …
[HTML][HTML] Lipid metabolism and cancer
H Cheng, M Wang, J Su, Y Li, J Long, J Chu, X Wan… - Life, 2022 - mdpi.com
Lipid metabolism is involved in the regulation of numerous cellular processes, such as cell
growth, proliferation, differentiation, survival, apoptosis, inflammation, movement, membrane …
growth, proliferation, differentiation, survival, apoptosis, inflammation, movement, membrane …
[HTML][HTML] Hepatocyte miR-34a is a key regulator in the development and progression of non-alcoholic fatty liver disease
Objective Hepatic miR-34a expression is elevated in diet-induced or genetically obese mice
and patients with non-alcoholic steatohepatitis (NASH), yet hepatocyte miR-34a's role in the …
and patients with non-alcoholic steatohepatitis (NASH), yet hepatocyte miR-34a's role in the …