The aminoacyl‐tRNA synthetases are prominently known for their classic function in the first
step of protein synthesis, where they bear the responsibility of setting the genetic code. Each …

Known as an essential component of the translational apparatus, the aminoacyl-tRNA
synthetase family catalyzes the first step reaction in protein synthesis, that is, to specifically …

Hypomyelinating disorders of the central nervous system are still a diagnostic challenge, as
many patients remain without genetic diagnosis. Using magnetic resonance imaging (MRI) …

Tryptophanyl tRNA synthetase (WRS) is an essential enzyme as it catalyzes the ligation of
tryptophan to its cognate tRNA during translation. Interestingly, mammalian WRS has …

In mammalian cells, aminoacyl-tRNA synthetases (aaRSs) are organized into a high-
molecular-weight multisynthetase complex whose cellular function has remained a mystery …

During mRNA translation, tRNAs are charged by aminoacyl-tRNA synthetases and
subsequently used by ribosomes. A multi-enzyme aminoacyl-tRNA synthetase complex …

Aminoacyl-tRNA synthetases are essential enzymes for interpreting the genetic code. They
are responsible for the proper pairing of codons on mRNA with amino acids. In addition to …

Aminoacyl‐tRNA synthetases (AaRSs) are valuable “housekeeping” enzymes that ensure
the accurate transmission of genetic information in living cells, where they aminoacylated …

Intricate evolutionary events enabled the emergence of the full set of aminoacyl-tRNA
synthetase (aaRS) families that define the genetic code. The diversification of aaRSs has …

Background Treatment of parasitic diseases has been challenging due to evolution of drug
resistant parasites, and thus there is need to identify new class of drugs and drug targets …