Aging is a major risk factor for a number of chronic diseases, including neurodegenerative
and cerebrovascular disorders. Aging processes have therefore been discussed as potential …

Aging is a dynamic, time-dependent process that is characterized by a gradual accumulation
of cell damage. Continual functional decline in the intrinsic ability of living organisms to …

Cardiovascular diseases (CVD) are predominantly an aging disease. Important sex-specific
differences exist and the mechanism (s) by which this sex-by-age interaction influences CVD …

The geroscience hypothesis proposes that addressing the biology of aging could directly
prevent the onset or mitigate the severity of multiple chronic diseases. Understanding the …

The gut microbiome plays a crucial role in host health throughout the lifespan by influencing
brain function during aging. The microbial diversity of the human gut microbiome decreases …

Progressive loss of physiological integrity and accumulation of degenerative changes
leading to functional impairment and increased susceptibility to diseases are the main …

Current research on human aging has largely been guided by the milestone paper
“hallmarks of aging,” which were first proposed in the seminal 2013 paper by Lopez‐Otin et …

Aging is a complex process that features a functional decline in many organelles. Various
factors influence the aging process, such as chromosomal abnormalities, epigenetic …

Inflammaging is a term used to describe the tight relationship between low-grade chronic
inflammation and aging that occurs during physiological aging in the absence of evident …

Mitochondria are the only organelles, along with the nucleus, that have their own DNA.
Mitochondrial DNA (mtDNA) is a double-stranded circular molecule of~ 16.5 kbp that can …