The role of the host extracellular matrix (ECM) in infection tends to be neglected. However,
the complex interactions between invading pathogens, host tissues and immune cells occur …

Actin and its ability to polymerize into dynamic filaments is critical for the form and function of
cells throughout the body. While multiple proteins have been characterized as affecting actin …

Prions, which cause fatal neurodegenerative disorders such as Creutzfeldt‐Jakob disease,
are misfolded and infectious protein aggregates. Currently, there are no treatments available …

Cellular form and function–and thus normal development and physiology–are specified via
proteins that control the organization and dynamic properties of the actin cytoskeleton. Using …

The cellular prion protein (PrP C) is a ubiquitously expressed protein of currently unresolved
but potentially diverse function. Of putative relevance to normal biological activity, PrP C is …

Preconditioning is a promising technique to protect the heart from ischaemia-reperfusion
injury. In this context, the crosstalk between different cardiac cell types and especially the …

Prion diseases are infectious protein misfolding disorders of the central nervous system that
result from misfolding of the cellular prion protein (PrP C) into the pathologic isoform PrP Sc …

Transmissible spongiform encephalopathies or prion disorders are fatal infectious diseases
that cause characteristic spongiform degeneration in the central nervous system. The …

The properties of infectious prions and the pathology of the diseases they cause are
dependent upon the unique conformation of each prion strain. How the pathology of prion …

Prions are infectious protein aggregates that cause several fatal neurodegenerative
diseases. Prion research has been hindered by a lack of cellular paradigms for studying the …