Hypoxia signaling in human diseases and therapeutic targets
Since the discovery of hypoxia-inducible factor (HIF), numerous studies on the hypoxia
signaling pathway have been performed. The role of HIF stabilization during hypoxia has …
signaling pathway have been performed. The role of HIF stabilization during hypoxia has …
Pharmacology of adenosine receptors: the state of the art
Adenosine is a ubiquitous endogenous autacoid whose effects are triggered through the
enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Due to the rapid …
enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Due to the rapid …
Adenosine as a multi-signalling guardian angel in human diseases: when, where and how does it exert its protective effects?
The importance of adenosine for human health cannot be overstated. Indeed, this ubiquitous
nucleoside is an integral component of ATP, and regulates the function of every tissue and …
nucleoside is an integral component of ATP, and regulates the function of every tissue and …
Purinergic regulation of neutrophil function
X Wang, D Chen - Frontiers in immunology, 2018 - frontiersin.org
Purinergic signaling, which utilizes nucleotides (particularly ATP) and adenosine as
transmitter molecules, plays an essential role in immune system. In the extracellular …
transmitter molecules, plays an essential role in immune system. In the extracellular …
The hypoxia-adenosine link during myocardial ischemia—reperfusion injury
Despite increasing availability and more successful interventional approaches to restore
coronary reperfusion, myocardial ischemia-reperfusion injury is a substantial cause of …
coronary reperfusion, myocardial ischemia-reperfusion injury is a substantial cause of …
[HTML][HTML] Targeting myocardial equilibrative nucleoside transporter ENT1 provides cardioprotection by enhancing myeloid Adora2b signaling
Previous studies implicate extracellular adenosine signaling in attenuating myocardial
ischemia and reperfusion injury (IRI). This extracellular adenosine signaling is terminated by …
ischemia and reperfusion injury (IRI). This extracellular adenosine signaling is terminated by …
Enteric glial adenosine 2B receptor signaling mediates persistent epithelial barrier dysfunction following acute DSS colitis
V Grubišić, V Bali, DE Fried, HK Eltzschig… - Mucosal …, 2022 - nature.com
Intestinal epithelial barrier function is compromised in inflammatory bowel disease and
barrier dysfunction contributes to disease progression. Extracellular nucleotides/nucleosides …
barrier dysfunction contributes to disease progression. Extracellular nucleotides/nucleosides …
Adenosine signalling to astrocytes coordinates brain metabolism and function
Brain computation performed by billions of nerve cells relies on a sufficient and
uninterrupted nutrient and oxygen supply,. Astrocytes, the ubiquitous glial neighbours of …
uninterrupted nutrient and oxygen supply,. Astrocytes, the ubiquitous glial neighbours of …
Acute enhancement of cardiac function by phosphodiesterase type 1 inhibition: translational study in the dog and rabbit
T Hashimoto, GE Kim, RS Tunin, T Adesiyun, S Hsu… - Circulation, 2018 - Am Heart Assoc
Background: Phosphodiesterase type-1 (PDE1) hydrolyzes cAMP and cGMP and is
constitutively expressed in the heart, although cardiac effects from its acute inhibition in vivo …
constitutively expressed in the heart, although cardiac effects from its acute inhibition in vivo …
The adenosine A2B G protein-coupled receptor: Recent advances and therapeutic implications
The adenosine A 2B receptor (A 2B AR) is one of four adenosine receptor subtypes
belonging to the Class A family of G protein-coupled receptors (GPCRs). Until recently, the A …
belonging to the Class A family of G protein-coupled receptors (GPCRs). Until recently, the A …