The scarcity of live human brain cells for experimental access has for a long time limited our
ability to study complex human neurological disorders and elucidate basic neuroscientific …

Neural stem cells (NSCs) have a unique role in neural regeneration. Cell therapy based on
NSC transplantation is a promising tool for the treatment of nervous system diseases …

The abilities of stem cells to self-renew and form different mature cells expand the
possibilities of applications in cell-based therapies such as tissue recomposition in …

Cellular reprogramming using chemically defined conditions, without genetic manipulation,
is a promising approach for generating clinically relevant cell types for regenerative …

Cellular heterogeneity in cancer represents a significant challenge. In order to develop
effective and lasting therapies, it is essential to understand the source of this heterogeneity …

The discovery of induced pluripotent stem cells changed the field of regenerative medicine
and inspired the technological development of direct reprogramming or the process by …

Direct neuronal reprogramming is an innovative new technology that involves the
conversion of somatic cells to induced neurons (iNs) without passing through a pluripotent …

Traumatic spinal cord injury (SCI) is a leading cause of lifelong disabilities. Permanent
sensory, motor and autonomic impairments after SCI are substantially attributed to …

Highlights•Step-by-step review of points to consider for successful in vitro disease
models.•Direct reprogramming/transdifferentiation versus directed in vitro differentiation.• …

Direct conversion of somatic cells into neural stem cells (NSCs) by defined factors holds
great promise for mechanistic studies, drug screening, and potential cell therapies for …