Ferroptosis, a form of regulated cell death, is initiated by oxidative perturbations of the
intracellular microenvironment, which is under the constitutive control of glutathione …

Reactive oxygen species (ROS), a group of ions and molecules, include hydroxyl radicals (·
OH), alkoxyl radicals, superoxide anion (O 2·−), singlet oxygen (1 O 2) and hydrogen …

Iron as an important element plays crucial roles in various physiological and pathological
processes. Iron metabolism behaves in systemic and cellular two levels that usually are in …

Iron is an essential element required by cells and has been described as a key player in
ferroptosis. Ferritin operates as a fundamental iron storage protein in cells forming …

Ferroptosis is an iron-dependent regulated cell death marked by excessive oxidative
phospholipids (PLs). The polyunsaturated fatty acids-containing phospholipids (PUFA-PLs) …

Background Gastric cancer stem cells (CSCs) are the main causes of metastasis and drug
resistance. We previously indicated that miR-375 can inhibit Helicobacter pylori-induced …

The role of autophagy in cancer onset and progression appears still controversial. On one
hand, autophagy allows cancer cell to survive in unfavorable environmental conditions, on …

Recent studies have revealed the critical roles of ferroptosis in different physiological and
pathological processes, however, its effects on the progression of colorectal cancer stem …

Cancer stem cells (CSCs) are a distinct subpopulation of tumor cells with stem cell-like
features. Able to initiate and sustain tumor growth and mostly resistant to anti-cancer …

Mitochondria are multifunctional cellular organelles that are major producers of reactive
oxygen species (ROS) in eukaryotes; to maintain the redox balance, they are supplemented …