Hippo signalling in the liver: role in development, regeneration and disease
JO Russell, FD Camargo - Nature reviews Gastroenterology & …, 2022 - nature.com
The Hippo signalling pathway has emerged as a major player in many aspects of liver
biology, such as development, cell fate determination, homeostatic function and …
biology, such as development, cell fate determination, homeostatic function and …
[HTML][HTML] YAP/TAZ at the roots of cancer
F Zanconato, M Cordenonsi, S Piccolo - Cancer cell, 2016 - cell.com
YAP and TAZ are highly related transcriptional regulators pervasively activated in human
malignancies. Recent work indicates that, remarkably, YAP/TAZ are essential for cancer …
malignancies. Recent work indicates that, remarkably, YAP/TAZ are essential for cancer …
[HTML][HTML] Long noncoding RNA GAS5 inhibits progression of colorectal cancer by interacting with and triggering YAP phosphorylation and degradation and is …
W Ni, S Yao, Y Zhou, Y Liu, P Huang, A Zhou, J Liu… - Molecular cancer, 2019 - Springer
Background YAP activation is crucial for cancer development including colorectal cancer
(CRC). Nevertheless, it remains unclear whether N6-Methyladenosine (m 6 A) modified …
(CRC). Nevertheless, it remains unclear whether N6-Methyladenosine (m 6 A) modified …
[HTML][HTML] The influence of nanotopography on cell behaviour through interactions with the extracellular matrix–A review
Nanotopography presents an effective physical approach for biomaterial cell manipulation
mediated through material-extracellular matrix interactions. The extracellular matrix that …
mediated through material-extracellular matrix interactions. The extracellular matrix that …
YAP/TAZ functions and their regulation at a glance
A Pocaterra, P Romani, S Dupont - Journal of cell science, 2020 - journals.biologists.com
ABSTRACT YAP and TAZ proteins are transcriptional coactivators encoded by paralogous
genes, which shuttle between the cytoplasm and the nucleus in response to multiple inputs …
genes, which shuttle between the cytoplasm and the nucleus in response to multiple inputs …
Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth
F Zanconato, M Forcato, G Battilana, L Azzolin… - Nature cell …, 2015 - nature.com
YAP/TAZ are nuclear effectors of the Hippo pathway regulating organ growth and
tumorigenesis. Yet, their function as transcriptional regulators remains underinvestigated. By …
tumorigenesis. Yet, their function as transcriptional regulators remains underinvestigated. By …
The biology of YAP/TAZ: hippo signaling and beyond
S Piccolo, S Dupont, M Cordenonsi - Physiological reviews, 2014 - journals.physiology.org
The transcriptional regulators YAP and TAZ are the focus of intense interest given their
remarkable biological properties in development, tissue homeostasis and cancer. YAP and …
remarkable biological properties in development, tissue homeostasis and cancer. YAP and …
YAP/TAZ: drivers of tumor growth, metastasis, and resistance to therapy
BJ Thompson - Bioessays, 2020 - Wiley Online Library
The transcriptional co‐activators YAP (or YAP1) and TAZ (or WWTR1) are frequently
activated during the growth and progression of many solid tumors, including lung, colorectal …
activated during the growth and progression of many solid tumors, including lung, colorectal …
Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis
Pathological fibrosis is driven by a feedback loop in which the fibrotic extracellular matrix is
both a cause and consequence of fibroblast activation. However, the molecular mechanisms …
both a cause and consequence of fibroblast activation. However, the molecular mechanisms …
[HTML][HTML] Signaling in fibrosis: TGF-β, WNT, and YAP/TAZ converge
B Piersma, RA Bank, M Boersema - Frontiers in medicine, 2015 - frontiersin.org
Chronic organ injury leads to fibrosis and eventually organ failure. Fibrosis is characterized
by excessive synthesis, remodeling, and contraction of extracellular matrix produced by …
by excessive synthesis, remodeling, and contraction of extracellular matrix produced by …