Rodent models have been fundamental to understand chronic pain (CP) pathophysiology
and to test for potential treatments. Pain assessment in CP models is most frequently based …

The neuropeptide S (NPS) and its receptor (NPSR1) have been extensively studied over the
last two decades for their roles in locomotion, arousal/wakefulness and anxiety-related and …

The number of studies on trigeminal nerve injury using animal models remains limited. A
rodent model of trigeminal neuropathic pain was first developed in 1994, in which chronic …

Irritable bowel syndrome (IBS) is characterized by recurrent abdominal discomfort,
spontaneous pain, colorectal hypersensitivity and bowel dysfunction. Patients with IBS also …

Clinical evidence indicates that cognitive impairment is a common comorbid condition of
chronic pain. However, the cellular basis for chronic pain–mediated cognitive impairment …

Anxiety continues to represent a major unmet medical need. Despite the availability of
numerous anxiolytic drugs, a large proportion of patients do not respond well to current …

Abstract Background The neuropeptide S/Neuropeptide S receptor (NPS/NPSR) system is
involved in the regulation of anxiety in rodents. Chronic inflammation can induce anxiety …

Anxiety frequently appears in patients with diabetic neuropathic pain, a highly prevalent
clinical condition. However, the neurobiological mechanisms of this comorbidity are poorly …

The nucleoredoxin gene NXNL2 encodes for two products through alternative splicing, rod-
derived cone viability factor-2 (RdCVF2) that mediates neuronal survival and the thioredoxin …

Neuropeptide S (NPS) is an endogenous peptide that regulates various physiological
functions, such as immune functions, anxiety-like behaviors, learning and memory, the sleep …