The proteins of the BCL-2 family are key regulators of mitochondrial apoptosis, acting as
either promoters or inhibitors of cell death. The functional interplay and balance between the …

Numerous mitochondrial constituents and metabolic products can function as damage-
associated molecular patterns (DAMPs) and promote inflammation when released into the …

Senescent cells drive age-related tissue dysfunction partially through the induction of a
chronic senescence-associated secretory phenotype (SASP). Mitochondria are major …

Mitochondria have recently emerged as key drivers of inflammation associated with cell
death. Many of the pro-inflammatory pathways activated during cell death occur upon …

Toxic effect of heavy metal cadmium (Cd) on fish kidneys had been reported. Mitochondrion
is an important organelle for maintaining kidney function, while its role in Cd-induced kidney …

The importance of mitochondrial dynamics, the physiological process of mitochondrial fusion
and fission, in regulating diverse cellular functions and cellular fitness has been well …

Apoptosis is a regulated cellular pathway that ensures that a cell dies in a structured fashion
to prevent negative consequences for the tissue or the organism. Dysfunctional apoptosis is …

Mitochondria are cellular organelles with a major role in many cellular processes, including
not only energy production, metabolism, and calcium homeostasis but also regulated cell …

Dysregulating cellular metabolism is one of the emerging cancer hallmarks. Mitochondria
are essential organelles responsible for numerous physiologic processes, such as energy …

Inflammatory bowel disease (IBD) is one of the main factors leading to colitis-associated
colorectal cancer (CAC). Therefore, it is critical to develop an effective treatment for IBD to …