Dysfunction of gamma-aminobutyric acid (GABA) and/or glutamate neurotransmitter systems
have increasingly been implicated in the aetiology of Major Depressive Disorder (MDD). It …

Perimenopause marks the transition from a woman's reproductive stage to menopause.
Usually occurring between 42 and 52 years of age, it is determined clinically by the onset of …

The neuroactive steroid allopregnanolone (ALLO) is an endogenous positive allosteric
modulator of GABA type A receptor (GABA AR), and the down-regulation of its biosynthesis …

The female lifespan is marked by periods of dramatic hormonal fluctuation. Changes in the
ovarian hormones estradiol and progesterone, in addition to the progesterone metabolite …

Abstract Background Abnormalities of GABAergic (gamma-aminobutyric acidergic) systems
may play a role in schizophrenia and mood disorders. Magnetic resonance spectroscopy …

The Gamma-aminobutyric acid (GABA) and glutamate (Glu) neurotransmitter systems are
implicated in depression. While previous studies found reduced GABA levels, and a …

Objective Perimenopause is associated with an increased risk of developing a major
depressive (MD) episode. A significant number of women develop their first MD episode …

Background Parkinson's disease (PD) is divided into postural instability gait difficulty (PIGD)
and tremor‐dominant (TD) subtypes. Increasing evidence has suggested that the GABAergic …

Objective The anterior cingulate cortex (ACC) is associated with the processing of negative
emotions. Gamma-aminobutyric acid (GABA) metabolism plays an important role in the …

Background The role of testosterone (T) in the pathophysiology of affective disorders and
anxiety is broadly supported. Evidence suggests that T has anxiolytic and antidepressant …