Xanthones and cancer: from natural sources to mechanisms of action

LC Klein‐Júnior, A Campos, R Niero… - Chemistry & …, 2020 - Wiley Online Library
Xanthones are a class of heterocyclic natural products that have been widely studied for
their pharmacological potential. In fact, they have been serving as scaffolds for the design of …

Recent updates on metabolite composition and medicinal benefits of mangosteen plant

WM Aizat, IN Jamil, FH Ahmad-Hashim, NM Noor - PeerJ, 2019 - peerj.com
Background Mangosteen (Garcinia mangostana L.) fruit has a unique sweet-sour taste and
is rich in beneficial compounds such as xanthones. Mangosteen originally been used in …

Garcinone E suppresses breast cancer growth and metastasis by modulating tumor‐associated macrophages polarization via STAT6 signaling

X Nie, L Fu, Y Cheng, X Wu, K Lv, R Li… - Phytotherapy …, 2023 - Wiley Online Library
Cancer metastasis remains the most common cause of death in breast cancer patients.
Tumor‐associated macrophages (TAMs) are a novel therapeutic target for the treatment of …

New Alpha-Amylase Inhibitory Metabolites from Pericarps of Garcinia mangostana

NA Alhakamy, GA Mohamed, UA Fahmy, BG Eid… - Life, 2022 - mdpi.com
Two new benzophenones: garcimangophenones A (6) and B (7) and five formerly reported
metabolites were purified from the pericarps EtOAc fraction of Garcinia mangostana ((GM) …

[HTML][HTML] Mangostanaxanthone VIIII, a new xanthone from Garcinia mangostana pericarps, α-amylase inhibitory activity, and molecular docking studies

SRM Ibrahim, GA Mohamed, MT Khayat… - Revista Brasileira de …, 2019 - SciELO Brasil
ABSTRACT A new xanthone: mangostanaxanthone VIIII [1, 3, 5, 6, 7-pentahydroxy-2-(3-
methylbut-2-enyl)-8-(3-hydroxy-3-methylbut-1-enyl) xanthone](5) and four known xanthones …

Garcixanthones B and C, new xanthones from the pericarps of Garcinia mangostana and their cytotoxic activity

SRM Ibrahim, HM Abdallah, AM El-Halawany… - Phytochemistry …, 2018 - Elsevier
Two new prenylated xanthones, garcixanthones B (1) and C (2) and six known metabolites:
gartanin (3), 1, 3, 8-trihydroxy-2-(3-methyl-2-butenyl)-4-(3-hydroxy-3-methylbutanoyl) …

The mechanisms of action of prenylated xanthones against breast, colon, and lung cancers, and their potential application against drug resistance

NV Gunter, SS Teh, I Jantan… - Phytochemistry …, 2023 - Springer
Cancers such as breast, colon, and lung cancers are among the leading causes of death
with alarming increases in the number of new diagnoses and mortality rates. The non …

Skrining fitokimia dan profil kromatografi lapis tipis (KLT) tumbuhan antimalaria asal Indonesia

M Arifuddin, M Bone - Jurnal Sains dan Kesehatan, 2020 - jsk.ff.unmul.ac.id
Telah dilakukan pengujian skrining fitokimia dengan tujuan mendeteksi senyawa metabolit
sekunder pada beberapa tumbuhan, yakni batang Brotowali (Tinospora crispa), daun …

α‐Amylase inhibition of xanthones from Garcinia mangostana pericarps and their possible use for the treatment of diabetes with molecular docking studies

SRM Ibrahim, GA Mohamed… - Journal of food …, 2019 - Wiley Online Library
Chromatographic separation of the methanol extract of Garcinia mangostana (mangosteen,
Guttiferae) dried pericarps led to the isolation and structural characterization of a new …

Mangostanaxanthone VIII, a new xanthone from Garcinia mangostana and its cytotoxic activity

SRM Ibrahim, HM Abdallah… - Natural product …, 2019 - Taylor & Francis
A new prenylated xanthone, mangostanaxanthone VIII (7) and six known metabolites:
gartanin (1), 1, 3, 8-trihydroxy-2-(3-methyl-2-butenyl)-4-(3-hydroxy-3-methylbutanoyl) …