There is increasing recognition that systematic post–cardiac arrest care after return of
spontaneous circulation (ROSC) can improve the likelihood of patient survival with good …

Background: Mild to moderate hypothermia (32–35 C) is the first treatment with proven
efficacy for postischemic neurological injury. In recent years important insights have been …

A decision to withdraw life-sustaining treatment (WLST) is derived by a conclusion that
further treatment will not enable a patient to survive or will not produce a functional outcome …

Background Cardiac arrest outside the hospital is common and has a poor outcome. Studies
in laboratory animals suggest that hypothermia induced shortly after the restoration of …

Background Cardiac arrest with widespread cerebral ischemia frequently leads to severe
neurologic impairment. We studied whether mild systemic hypothermia increases the rate of …

Objective: Oxygen is vital during critical illness, but hyperoxia may harm patients. Our aim
was to systematically evaluate the methodology and findings of cohort studies investigating …

The susceptibility of the brain to ischaemic injury dramatically limits its viability following
interruptions in blood flow. However, data from studies of dissociated cells, tissue …

Current knowledge regarding the pathophysiology of cerebral ischemia and brain trauma
indicates that similar mechanisms contribute to loss of cellular integrity and tissue …

Background Moderate elevation of brain temperature, when present during or after
ischemia, may markedly worsen the resulting injury. Objective To evaluate the impact of …

Hypocapnia, defined as low partial pressure of arterial blood carbon dioxide, is usually well
tolerated and often has no apparent effects. Although transient induction of hypocapnia can …