Oxidative stress and AKT serine-threonine kinase (AKT) are responsible for regulating
several cell functions of cancer cells. Several natural products modulate both oxidative …

Background The insulin/IGF-1 signaling pathway has a major role in the regulation of
longevity both in Caenorhabditis elegans and mammalian species, ie, reduced activity of …

In developing and validating the concept of frailty as a geriatric syndrome, it has been
necessary to distinguish the clinical expression of frailty from normal age-related changes …

Chronic obstructive pulmonary disease/emphysema (COPD/emphysema) is characterized
by chronic inflammation and premature lung aging. Anti-aging sirtuin 1 (SIRT1), a NAD+ …

Members of the FOXO (forkhead O) class of transcription factors are tumor suppressors that
also control aging and organismal life span. Mammalian FOXO degradation is proteasome …

The insulin-like growth factor (IGF) signaling pathway plays a crucial role in the regulation of
cell growth, differentiation, apoptosis, and aging. IGF-binding proteins (IGFBPs) are …

Forkhead transcription factors have a 'winged helix'domain and regulate processes that
range from cell longevity to cell death. Of the mammalian forkhead family members in the O …

FOXO3 is consistently annotated as a human longevity gene. However, functional variants
and underlying mechanisms for the association remain unknown. Here, we perform …

Abstract Harman's Free Radical Theory of Aging has been considered as a major theory of
aging for more than 50 years. In 1956 Dr. Harman proposed that the accumulation of free …

Cellular senescence is a stress-response phenomenon in which cells lose the ability to
proliferate; it is induced by telomere shortening, activation of oncogenes or tumor …