The mechanism of corneal wound healing has not been clarified yet. However, evidence
has accumulated that various kinds of growth factor such as epidermal growth factor (EGF) …

In mammals, tissue damage is usually repaired by activation of a fibrotic response which
saves the life of the organism, but which can never restore function to the damaged organ. In …

The growth and differentiation factor transforming growth factor-β2 (TGFβ2) is thought to play
important roles in multiple developmental processes. Targeted disruption of the TGF β2 …

By using the highly sensitive and specific technique of enzyme-linked immunosorbent
assay, we investigated the presence and amount of transforming growth factor-β2 (TGF-β2) …

Down‐regulation of the transforming growth factor‐beta (TGF‐β) signaling system is a
strategy for preventing scarring during wound healing. Human corneal and limbal fibroblasts …

Abstract T helper (Th)-17 is a recently identified subtype of Th response that has been
implicated in host defense and autoimmunity. We investigated whether there is evidence for …

Optic nerve degeneration caused by glaucoma is a leading cause of blindness worldwide.
Patients affected by the normal-pressure form of glaucoma are more likely to harbor risk …

Myofibroblasts, defined by their expression of smooth muscle alpha-actin, appear at corneal
and dermal incisions and promote wound contraction. We report here that cultured …

The TGF-β signaling pathway plays a crucial role in several key aspects of development and
tissue homeostasis. TGF-β ligands and their mediators have been shown to be important …

Transforming growth factor-β2 (TGF-β2) is found in increasing amounts in aqueous humor
and reactive optic nerve astrocytes of patients with primary open-angle glaucoma (POAG), a …