Plasma lipoprotein (a)[L p (a)] is a quantitative genetic trait with a very broad and skewed
distribution, which is largely controlled by genetic variants at the LPA locus on chromosome …

Elevated plasma concentrations of lipoprotein (a)[Lp (a)] have been determined to be a
causal risk factor for coronary heart disease, and may similarly play a role in other …

The degree and the origins of quantitative variability of most human plasma proteins are
largely unknown. Because the twin study design provides a natural opportunity to estimate …

Human epidemiologic and genetic evidence using the Mendelian randomization approach
in large-scale studies now strongly supports that elevated lipoprotein (a)[Lp (a)] is a causal …

Levels of lipoprotein (a)[Lp (a)], a complex between an LDL-like lipid moiety containing one
copy of apoB, and apo (a), a plasminogen-derived carbohydrate-rich hydrophilic protein, are …

Although mass spectrometry (MS) of metabolites has the potential to provide real‐time
monitoring of patient status for diagnostic purposes, the diagnostic application of MS is …

The field of human genetic variations has progressed rapidly over the past few years. It has
added much information and deepened our knowledge and understanding of the diversity of …

The recent discovery of 5-hydroxymethylcytosine (5hmC), an epigenetic modifier and
oxidation product of 5-methylcytosine (5mC), has broadened the scope and understanding …

Abstract Lipoprotein (a)[Lp (a)] is an independent risk factor for atherosclerosis-related
events that is under strong genetic control (heritability= 0.68–0.98). However, causal …

Elevated plasma concentrations of lipoprotein (a)(Lp (a)) are a causal risk factor for coronary
heart disease (CHD) and calcific aortic valve stenosis (CAVS). Genetic, epidemiological and …