Biosensing and diagnostic platforms with high sensitivity, specificity, and fast response time
are based on immobilized biomolecules such as antibodies (Abs), aptamers, enzymes …

Because of its piconewton force sensitivity and nanometer positional accuracy, the atomic
force microscope (AFM) has emerged as a powerful tool for exploring the forces and the …

A novel reagent for low-level detection in immunoadsorbent assays is described. The
reagent consists of gold nanoparticles modified to integrate bioselective species (eg …

Protein biochips are at the heart of many medical and bioanalytical applications. Increasing
interest has been focused on surface activation and subsequent functionalization strategies …

The use of self-assembled monolayers (SAMs) in various fields of research is rapidly
growing. In particular, many biomedical fields apply SAMs as an interface-layer between a …

Bioanalytical science is experiencing a period of unprecedented growth. Drivers behind this
growth include the need to detect markers central to human and veterinary diagnostics at …

Novel detection strategies that exploit the unique properties of gold nanoparticles (AuNPs)
hold great promise for the advancement of diagnostic testing. Fundamental to many of these …

This Account focuses on our recent and systematic effort in the development of generic
scanning probe lithography (SPL)-based methodologies to produce nanopatterns of self …

An immunoassay readout method based on surface-enhanced Raman scattering (SERS) is
described. The method exploits the SERS-derived signal from reporter molecules that are …

This article describes the design, function, and application of simple microfluidic networks as
conduits for the patterned delivery of chemical reactants onto a substrate. It demonstrates …