Targeted drug delivery in the brain is instrumental in the treatment of lethal brain diseases,
such as glioblastoma multiforme, the most aggressive primary central nervous system …

Designing scaffolds for polyplex-mediated therapeutic gene delivery has a number of
applications in regenerative medicine, such as for tissue repair after wounding or disease …

Neurological disorders affect billions of people across the world, making the discovery of
effective treatments an important challenge. The evaluation of drug efficacy is further …

Three-D head geometrical models of eight healthy subjects and 11 hydrocephalus patients
were built using their CINE phase-contrast MRI data and used for computer simulations …

The biomechanical characterization of human brain tissue and the development of
appropriate mechanical models is crucial to provide realistic computational predictions that …

The brain is arguably the most complex human organ and modelling its mechanical
behaviour has challenged researchers for decades. There is still a lack of understanding on …

Brain tissue is one of the softest tissues in the human body and the quantification of its
mechanical properties has challenged scientists over the past decades. Associated …

Multiple-porosity models are commonly used to describe the poromechanical behavior of
complex porous solids occurring in earth and life sciences. From the characterization …

Analytical solutions to the classical Mandel's problem play an important role in
understanding Biot's theory of poroelasticity and validating geomechanics numerical …

Self-consistent extension of linear poroelasticity (Biot 1941) to overlapping systems or
scales of porosity and permeability within fluid-saturated, elastic materials is presented. An …