The hexadehydro-Diels–Alder (HDDA) reaction is the thermal cyclization of an alkyne and a
1, 3-diyne to generate a benzyne intermediate. This is then rapidly trapped, in situ, by a …

The hexadehydro-Diels–Alder (HDDA) reaction between an alkyne and a 1, 3-diyne has
recently become a rapidly growing area in the field of aryne chemistry. Both concerted and …

Recent developments in aryne chemistry are reviewed with a particular focus on synthetic
methods. This includes an overview of the precursors of arynes and their activators; the …

An aryne 1, 2, 3-trisubstitution with aryl allyl sulfoxides is accomplished, featuring an
incorporation of C–S, C–O, and C–C bonds on the consecutive positions of a benzene ring …

An important question in organic chemistry concerns the extent to which benzynes—one of
the classical reactive intermediates in organic chemistry—can react in discriminating fashion …

We report here reactions of alkyl sulfides with benzynes thermally generated by the
hexadehydro-Diels–Alder (HDDA) cycloisomerization. The initially produced 1, 3-betaine (o …

The homo anion–cation coupling of cyclic diaryl λ3-bromanes/diarylbrominiums, which was
not reported in previous reports, has been disclosed for the first time. The competition …

We demonstrate that the hexadehydro-Diels–Alder (HDDA) cycloisomerization reaction to
produce reactive benzyne derivatives can be initiated photochemically. As with the thermal …

Transition metal-free intramolecular hydride transfer onto arynes is reported for the first time.
This unique transformation is utilized in redox-neutral intermolecular α-functionalization …

Abstract In the classic Diels–Alder [4+ 2] cycloaddition reaction, the overall degree of
unsaturation (or oxidation state) of the 4π (diene) and 2π (dienophile) pairs of reactants …