The initiation of replication is the central event in the bacterial cell cycle. Cells control the
rate of DNA synthesis by modulating the frequency with which new chains are initiated, like …

Bacteriophages (prokaryotic viruses) are favourite model systems to study DNA replication
in prokaryotes, and provide examples for every theoretically possible replication …

The initiation of chromosome replication in Escherichia coli requires the recruitment of the
replicative helicase DnaB from the DnaBC complex to the unwound region within the …

Cellular replication forks are powered by ring-shaped, hexameric helicases that encircle and
unwind DNA. To better understand the molecular mechanisms and control of these …

Primase and DnaB helicase play central roles during DNA replication initiation and
elongation. Both enzymes are drug targets because they are essential, persistent among …

The replisome is a multi-component molecular machine responsible for rapidly and
accurately copying the genome of an organism. A central member of the bacterial replisome …

The increasing prevalence of drug-resistant bacterial infections demands the development
of new antibacterials that are not subject to existing mechanisms of resistance. Previously …

Initiation and synthesis of RNA primers in the lagging strand of the replication fork in
Escherichia coli requires the replicative DnaB helicase and the DNA primase, the DnaG …

The replicative DNA helicase translocates on single-stranded DNA to drive replication forks
during chromosome replication. In most bacteria the ubiquitous replicative helicase, DnaB …

DNA helicases are motor proteins that play essential roles in DNA replication, repair and
recombination. In the replicative hexameric helicase, the fundamental reaction is the …