Nuclear receptor crosstalk can be defined as the interplay between different nuclear
receptors or between their overlapping signalling pathways. A subset of nuclear receptors …

Simple Summary Prostate cancer is the second most common cancer in men world-wide,
with nearly 1.3 million new cases each year, and over the next twenty years the incidence …

Mutations of the androgen receptor (AR) associated with prostate cancer and androgen
insensitivity syndrome may profoundly influence its structure, protein interaction network …

Cancer development, growth, and metastasis are highly regulated by several transcription
regulators (TRs), namely transcription factors, oncogenes, tumor-suppressor genes, and …

Nuclear receptors (NRs) are a superfamily of ligand-activated transcription factors that act as
biological sensors and use a combination of mechanisms to modulate positively and …

The glucocorticoid receptor (GR) is a ubiquitously expressed transcription factor that controls
metabolic and homeostatic processes essential for life. Although numerous crystal structures …

Steroid receptors (SRs) constitute an important class of signal-dependent transcription
factors (TFs). They regulate a variety of key biological processes and are crucial drug targets …

Androgens are an important class of C19 steroid hormones that control normal male
development and reproductive function. The main circulating androgen is testosterone …

Allosteric pathways in proteins describe networks comprising amino acid residues which
may facilitate the propagation of signals between distant sites. Through inter-residue …

The nuclear thyroid hormone receptors (THRs) are key mediators of thyroid hormone
function on the cellular level via modulation of gene expression. Two different genes encode …