Autoreactive B cells and interferons are central players in systemic lupus erythematosus
(SLE) pathogenesis. The partial success of drugs targeting these pathways, however …

The third edition of Flow Cytometry Guidelines provides the key aspects to consider when
performing flow cytometry experiments and includes comprehensive sections describing …

Psoriasis is a common, chronic immune-mediated systemic disease that had no effective
and durable treatment. Mesenchymal stem cells (MSCs) have immunomodulatory …

The discovery of IL-10 more than 30 years ago marked the beginning of our understanding
of how cytokines regulate immune responses, based on cross-regulation between Th1 and …

T follicular helper (Tfh) cells are heterogeneous and mainly characterized by expressing
surface markers CXCR5, ICOS, and PD-1; cytokine IL-21; and transcription factor Bcl6. They …

Regulatory T (Treg) cells are a barrier for tumor immunity and a target for immunotherapy.
Using single-cell transcriptomics, we found that CD4+ T cells infiltrating primary and …

Пандемия коронавирусной болезни 2019 (coronavirus disease, COVID-19),
этиологически связанной с вирусом SARS-CoV-2 (severe acute respiratory syndrome …

IL-10 is a cytokine with pleiotropic functions, particularly known for its suppressive effects on
various immune cells. Consequently, it can limit the pathogenesis of inflammatory diseases …

T helper cells aid B cells with the production of antibodies and thus play a central role in
disease development of systemic lupus erythematosus (SLE). Numerous T helper cell …

B cells have a prominent role in the pathogenesis of systemic lupus erythematosus (SLE).
They are mediators of inflammation through the production of pathogenic antibodies that …