Periodontitis and osteoporosis are prevalent inflammation‐associated skeletal disorders that
pose significant public health challenges to our aging population. Both periodontitis and …

Reactive oxygen species (ROS) and free radicals are essential for transmission of cell
signals and other physiological functions. However, excessive amounts of ROS can cause …

The immune and skeletal systems share a variety of molecules, including cytokines,
chemokines, hormones, receptors, and transcription factors. Bone cells interact with immune …

Mesenchymal stromal cells (MSCs) are promising candidates for tissue engineering and
regenerative medicine. The multipotent stem cell component of MSC isolates is able to …

Accumulating evidence indicates that intracellular reactive oxygen species (ROS)
production is highly involved in bone homeostasis by intervening osteoclast or osteoblast …

Clinical evidence links arterial calcification and cardiovascular risk. Finite-element modelling
of the stress distribution within atherosclerotic plaques has suggested that subcellular …

Significance: Oxidative stress, an excess of reactive oxygen species (ROS) production
versus consumption, may be involved in the pathogenesis of different diseases. The only …

Altered metabolism has been implicated in the pathogenesis of inflammatory diseases.
NADPH oxidase 4 (NOX4), a source of cellular superoxide anions, has multiple biological …

Osteoclasts are cells derived from bone marrow macrophages and are important in
regulating bone resorption during bone homeostasis. Understanding what drives osteoclast …

Osteoporosis is becoming a major concern in the field of public health. The process of bone
loss is insidious and does not directly induce obvious symptoms. Complications indicate an …