Acidobacteria represents an underrepresented soil bacterial phylum whose members are
pervasive and copiously distributed across nearly all ecosystems. Acidobacterial sequences …

BACKGROUND Two developments in distinct fields are converging to create interest in
discovering small molecules from the human microbiome. First, the use of genomics to guide …

Genome mining of biosynthetic pathways with no identifiable core enzymes can lead to
discovery of the so-called unknown (biosynthetic route)–unknown (molecular structure) …

Although biosynthetic gene clusters (BGCs) have been discovered for hundreds of bacterial
metabolites, our knowledge of their diversity remains limited. Here, we used a novel …

Metal-binding natural products contribute to metal acquisition and bacterial virulence, but
their roles in metal stress response are underexplored. We show that a five-enzyme pathway …

Plant growth-promoting rhizobacteria (PGPR) are naturally occurring soil bacteria that
aggressively colonize plant roots and benefit plants by providing growth promotion …

Methanotrophs, cells that consume methane (CH4) as their sole source of carbon and
energy, play key roles in the global carbon cycle, including controlling anthropogenic and …

High-affinity iron acquisition is mediated by siderophore-dependent pathways in the majority
of pathogenic and nonpathogenic bacteria and fungi. Considerable progress has been …

Iron is one of the major limiting factors and essential nutrients of microbial life. Since in
nature it is not readily available in the preferred form, microorganisms produce small high …

The complete genomes of three strains from the phylum Acidobacteria were compared.
Phylogenetic analysis placed them as a unique phylum. They share genomic traits with …