Native mass spectrometry (MS) involves the analysis and characterization of
macromolecules, predominantly intact proteins and protein complexes, whereby as much as …

Familial cases of Parkinson's disease (PD) can be associated with overexpression or
mutation of α‐synuclein, a synaptic protein reported to be localized mainly in the cytosol and …

Introduction: The ancient and ubiquitous monoamine signalling molecules serotonin,
dopamine, norepinephrine, and epinephrine are involved in multiple physiological functions …

Apoptosis signal-regulating kinase 1 (ASK1, also known as MAP3K5), a member of the
mitogen-activated protein kinase kinase kinase (MAP3K) family, regulates diverse …

Tyrosine hydroxylase (TH) is a multi‐domain, homo‐oligomeric enzyme that catalyses the
rate‐limiting step of catecholamine neurotransmitter biosynthesis. Missense variants of …

Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in the biosynthesis of
catecholamine neurotransmitters. TH is a highly complex enzyme at mechanistic, structural …

Increasing lines of evidence support the causal link between α-synuclein (α-syn)
accumulation in the brain and Parkinson's disease (PD) pathogenesis. Therefore, lowering α …

Tyrosine hydroxylase (TH) catalyzes the conversion of l-tyrosine into l-DOPA, which is the
rate-limiting step in the synthesis of catecholamines, such as dopamine, in dopaminergergic …

Highlights•The aromatic amino acid hydroxylases contain catalytic and regulatory
domains.•The regulatory domains of tyrosine and phenylalanine hydroxylase are ACT …

Monoamines critically modulate neurophysiological functions affected in several
neuropsychiatric disorders. We therefore examined genes encoding key enzymes of …