Cholangiocytes, the epithelial cells lining the intrahepatic and extrahepatic bile ducts, are
highly specialized cells residing in a complex anatomic niche where they participate in bile …

The mammalian Slc4 (Solute carrier 4) family of transporters is a functionally diverse group
of 10 multi-spanning membrane proteins that includes three Cl-HCO3 exchangers (AE1–3) …

Abstract Water channels, aquaporins (AQPs), are a family of small integral plasma
membrane proteins that primarily transport water across the plasma membrane. There are …

Abstract The BA-responsive GPCRs S1PR2 and TGR5 are almost ubiquitously expressed in
human and rodent tissues. In the liver, S1PR2 is expressed in all cell types, while TGR5 is …

The formation of bile depends on the structural and functional integrity of the bile-secretory
apparatus and its impairment, in different situations, results in the syndrome of cholestasis …

SUMMARY Plasmalemmal Cl–/HCO3–exchangers are encoded by the SLC4 and SLC26
gene superfamilies, and function to regulate intracellular pH,[Cl–] and cell volume. The Cl …

Plasmalemmal Cl−–HCO3− exchangers regulate intracellular pH and [Cl−] and cell volume.
In polarized epithelial cells, they contribute also to transepithelial secretion and reabsorption …

Three aquaporins are expressed in the brain. AQP4, the predominant brain water channel,
is expressed in astrocyte endfeet facing brain capillaries, perisynaptic spaces, and nodes of …

Many regulatory pathways are involved in liver regeneration after partial hepatectomy (PH)
to initiate growth, protect liver cells, and sustain functions of the remnant liver. Bile acids …

Abstract Ezrin/radixin/moesin (ERM) proteins function as general cross-linkers between
plasma membrane proteins and the actin cytoskeleton and are involved in the functional …