Despite much effort, synthetic small diameter vascular grafts still face limited success due to
vascular wall thickening known as intimal hyperplasia (IH). Compliance mismatch between …

The homologous to the E6-AP carboxyl terminus (HECT)-type E3 ubiquitin ligases are the
selective executers in the protein ubiquitination, playing a vital role in modulation of the …

Tumor cells metastasize from a primary lesion to distant organs mainly through
hematogenous dissemination, in which tumor cell re-adhesion to the endothelium is …

Cell death of endothelial cells (ECs) is a common devastating consequence of various
vascular-related diseases. Atherosclerosis, hypertension, sepsis, diabetes, cerebral …

Objective To explore the role of hemodynamic factors in the occurrence of superior
mesenteric artery (SMA) dissection (SMAD) using a fluid–structure interaction (FSI) …

Human endogenous retrovirus-H long terminal repeat-associating 2 (HHLA2) is a newly
emerging immune checkpoint that belongs to B7 family. HHLA2 has a co-stimulatory …

Endothelial shear stress is a tangential stress derived from the friction of the flowing blood
on the endothelial surface of the arterial wall and is expressed in units of force/unit area …

Proteoglycans and selected extracellular matrix constituents are emerging as intrinsic and
critical regulators of evolutionarily conversed, intracellular catabolic pathways. Often, these …

Endothelial cells (ECs) continuously sense and adapt to changes in shear stress generated
by blood flow. Here, we show that the activation of the mechanosensitive channel Piezo1 by …

Background The cell adhesion molecule transmembrane and immunoglobulin (Ig) domain
containing1 (TMIGD1) is a novel tumor suppressor that plays important roles in regulating …