The tumorigenic liver fluke Opisthorchis viverrini–multiple pathways to cancer

B Sripa, PJ Brindley, J Mulvenna, T Laha, MJ Smout… - Trends in …, 2012 - cell.com
Liver fluke infection caused by Opisthorchis viverrini is a major public health problem in
Thailand and adjacent countries. In addition to infection-associated morbidity, infection with …

Liver fluke vaccines in ruminants: strategies, progress and future opportunities

H Toet, DM Piedrafita, TW Spithill - International journal for parasitology, 2014 - Elsevier
The development of a vaccine for Fasciola spp. in livestock is a challenge and would be
advanced by harnessing our knowledge of acquired immune mechanisms expressed by …

Whole-genome sequence of Schistosoma haematobium

ND Young, AR Jex, B Li, S Liu, L Yang, Z Xiong, Y Li… - Nature …, 2012 - nature.com
Schistosomiasis is a neglected tropical disease caused by blood flukes (genus
Schistosoma; schistosomes) and affecting 200 million people worldwide. No vaccines are …

Carcinogenic liver fluke secretes extracellular vesicles that promote cholangiocytes to adopt a tumorigenic phenotype

S Chaiyadet, J Sotillo, M Smout… - The Journal of …, 2015 - academic.oup.com
Abstract Background. Throughout Asia, there is an unprecedented link between
cholangiocarcinoma and infection with the liver fluke Opisthorchis viverrini. Multiple …

The Opisthorchis viverrini genome provides insights into life in the bile duct

ND Young, N Nagarajan, SJ Lin, PK Korhonen… - Nature …, 2014 - nature.com
Opisthorchiasis is a neglected, tropical disease caused by the carcinogenic Asian liver fluke,
Opisthorchis viverrini. This hepatobiliary disease is linked to malignant cancer …

Non-model organisms, a species endangered by proteogenomics

J Armengaud, J Trapp, O Pible, O Geffard… - Journal of …, 2014 - Elsevier
Previously, large-scale proteomics was possible only for organisms whose genomes were
sequenced, meaning the most common model organisms. The use of next-generation …

[HTML][HTML] Liver fluke-associated biliary tract cancer

P Prueksapanich, P Piyachaturawat, P Aumpansub… - Gut and liver, 2018 - ncbi.nlm.nih.gov
Cholangiocarcinoma (CCA) is an aggressive cancer arising from epithelial cells of the bile
duct. Most patients with CCA have an unresectable tumor at the time of diagnosis. In …

Why does infection with some helminths cause cancer?

PJ Brindley, JMC Da Costa, B Sripa - Trends in cancer, 2015 - cell.com
Infections with Opisthorchis viverrini, Clonorchis sinensis, and Schistosoma haematobium
are classified as group 1 biological carcinogens: definitive causes of cancer. These worms …

The draft genome of the carcinogenic human liver fluke Clonorchis sinensis

X Wang, W Chen, Y Huang, J Sun, J Men, H Liu, F Luo… - Genome biology, 2011 - Springer
Background Clonorchis sinensis is a carcinogenic human liver fluke that is widespread in
Asian countries. Increasing infection rates of this neglected tropical disease are leading to …

Proteomic characterisation of Echinococcus granulosus hydatid cyst fluid from sheep, cattle and humans

A Aziz, W Zhang, J Li, A Loukas, DP McManus… - Journal of …, 2011 - Elsevier
The hydatid cyst fluid (HCF) of Echinococcus granulosus is a complex biological mixture
containing a wide range of proteins of both parasite and host origin. Using a combination of …