[HTML][HTML] PPARgamma in metabolism, immunity, and cancer: unified and diverse mechanisms of action
M Hernandez-Quiles, MF Broekema… - Frontiers in …, 2021 - frontiersin.org
The proliferator-activated receptor γ (PPARγ), a member of the nuclear receptor superfamily,
is one of the most extensively studied ligand-inducible transcription factors. Since its …
is one of the most extensively studied ligand-inducible transcription factors. Since its …
PPAR-γ signaling in nonalcoholic fatty liver disease: Pathogenesis and therapeutic targets
H Chen, H Tan, J Wan, Y Zeng, J Wang… - Pharmacology & …, 2023 - Elsevier
Non-alcoholic fatty liver disease (NAFLD), currently the leading cause of global chronic liver
disease, has emerged as a major public health problem, more efficient therapeutics of which …
disease, has emerged as a major public health problem, more efficient therapeutics of which …
[HTML][HTML] What we talk about when we talk about fat
ED Rosen, BM Spiegelman - Cell, 2014 - cell.com
There has been an upsurge of interest in the adipocyte coincident with the onset of the
obesity epidemic and the realization that adipose tissue plays a major role in the regulation …
obesity epidemic and the realization that adipose tissue plays a major role in the regulation …
PPARγ signaling and metabolism: the good, the bad and the future
Thiazolidinediones (TZDs) are potent insulin sensitizers that act through the nuclear
receptor peroxisome proliferator-activated receptor-γ (PPARγ) and are highly effective oral …
receptor peroxisome proliferator-activated receptor-γ (PPARγ) and are highly effective oral …
[HTML][HTML] Thiazolidinediones and the promise of insulin sensitization in type 2 diabetes
Type 2 diabetes is caused by insulin resistance coupled with an inability to produce enough
insulin to control blood glucose, and thiazolidinediones (TZDs) are the only current …
insulin to control blood glucose, and thiazolidinediones (TZDs) are the only current …
[HTML][HTML] The origins and drivers of insulin resistance
AMF Johnson, JM Olefsky - Cell, 2013 - cell.com
Obesity-induced insulin resistance is the major determinant of metabolic syndrome, which
precedes the development of type 2 diabetes mellitus and is thus the driving force behind …
precedes the development of type 2 diabetes mellitus and is thus the driving force behind …
[HTML][HTML] PPARγ agonists induce a white-to-brown fat conversion through stabilization of PRDM16 protein
Brown adipose tissue dissipates energy through heat and functions as a defense against
cold and obesity. PPARγ ligands have been shown to induce the browning of white …
cold and obesity. PPARγ ligands have been shown to induce the browning of white …
PPARs at the crossroads of lipid signaling and inflammation
W Wahli, L Michalik - Trends in Endocrinology & Metabolism, 2012 - cell.com
Nuclear receptors (NRs) are ligand-dependent transcription factors whose activation affects
genes controlling vital processes. Among them, the peroxisome proliferator-activated …
genes controlling vital processes. Among them, the peroxisome proliferator-activated …
The inflammatory response in sepsis
M Bosmann, PA Ward - Trends in immunology, 2013 - cell.com
The pathophysiology of sepsis and its accompanying systemic inflammatory response
syndrome (SIRS) and the events that lead to multiorgan failure and death are poorly …
syndrome (SIRS) and the events that lead to multiorgan failure and death are poorly …
[HTML][HTML] Functional regulation of PPARs through post-translational modifications
R Brunmeir, F Xu - International journal of molecular sciences, 2018 - mdpi.com
Peroxisome proliferator-activated receptors (PPARs) belong to the nuclear receptor
superfamily and they are essential regulators of cell differentiation, tissue development, and …
superfamily and they are essential regulators of cell differentiation, tissue development, and …