The cysteine protease legumain (also known as asparaginyl endopeptidase or δ-secretase)
is the only known mammalian asparaginyl endopeptidase and is primarily localized to the …

Alzheimer's disease (AD) is the most common form of dementia and cases are rising
worldwide. The effort to fight this disease is hampered by a lack of disease-modifying …

Triggering receptor expressed on myeloid cells 2 (TREM2) is a transmembrane protein that
is predominantly expressed by microglia in the brain. The proteolytic shedding of TREM2 …

Hearing loss is associated with an increased risk of Alzheimer disease (AD). However, the
mechanisms of hearing loss promoting the onset of AD are poorly understood. Here we …

Focal segmental glomerulosclerosis (FSGS) is the most common glomerular disorder
causing end-stage renal diseases worldwide. Central to the pathogenesis of FSGS is …

The bridging integrator 1 (BIN1) gene is an important risk locus for late-onset Alzheimer's
disease (AD). BIN1 protein has been reported to mediate tau pathology, but the underlying …

The Cdk5 kinase plays prominent roles in nervous system development, plasticity, behavior
and disease. It also has important, non-neuronal functions in cancer, the immune system …

The locus coeruleus noradrenergic (LC-NE) system provides a widespread innervation to
the CNS. Through both targeted and diffuse projections, this system has a major role in the …

Silica nanoparticles (SiO2 NPs) are increasingly investigated for their potential in drug
delivery systems. However, the neurotoxicity of SiO2 NPs remains to be fully clarified …

Neurodegenerative Tauopathies are a part of several neurological disorders and aging-
related diseases including, but not limited to, Alzheimer's Disease, Frontotemporal Dementia …