Seizing the fate of lymph nodes in immunotherapy: To preserve or not?

ZY Xu, ZZ Li, LM Cao, NN Zhong, XH Liu, GR Wang… - Cancer Letters, 2024 - Elsevier
Lymph node dissection has been a long-standing diagnostic and therapeutic strategy for
metastatic cancers. However, questions over myriad related complications and survival …

[HTML][HTML] Innate and adaptive immune responses that control lymph-borne viruses in the draining lymph node

CR Melo-Silva, LJ Sigal - Cellular & Molecular Immunology, 2024 - nature.com
The interstitial fluids in tissues are constantly drained into the lymph nodes (LNs) as lymph
through afferent lymphatic vessels and from LNs into the blood through efferent lymphatics …

Vaccine adjuvants: Tailoring innate recognition to send the right message

EC Lavelle, CP McEntee - Immunity, 2024 - cell.com
Adjuvants play pivotal roles in vaccine development, enhancing immunization efficacy
through prolonged retention and sustained release of antigen, lymph node targeting, and …

The role of lymphatic endothelial cell metabolism in lymphangiogenesis and disease

S Simeroth, P Yu - Frontiers in Cardiovascular Medicine, 2024 - frontiersin.org
Lymphatic endothelial cells (LECs) line lymphatic vessels, which play an important role in
the transport of lymph fluid throughout the human body. An organized lymphatic network …

The emerging role of effector functions exerted by tissue-resident memory T cells

N Iijima - Oxford Open Immunology, 2024 - academic.oup.com
The magnitude of the effector functions of memory T cells determines the consequences of
the protection against invading pathogens and tumor development or the pathogenesis of …

NK Cells in the Lymph Nodes and Their Role in Anti-Tumour Immunity

LV Graham, SI Khakoo, MD Blunt - Biomedicines, 2024 - mdpi.com
The lymph nodes are vital to enable adaptive immune responses to infection. Natural killer
(NK) cells are cytotoxic lymphocytes that directly kill cancer cells and modulate the activation …

Dendritic cells steering antigen and leukocyte traffic in lymph nodes

E Dotta, AK Maciola, T Baccega, G Pasqual - FEBS letters - Wiley Online Library
Dendritic cells (DCs) play a central role in initiating and shaping the adaptive immune
response, thanks to their ability to uptake antigens and present them to T cells. Once in the …

Sphingolipids as modulators of T cell function

P Cruz de Casas - 2024 - opus.bibliothek.uni-wuerzburg.de
The immune system is responsible for the preservation of homeostasis whenever a given
organism is exposed to distinct kinds of perturbations. Given the complexity of certain …

[图书][B] From vaccination to infection: mechanistic studies of immune responses to SARS-CoV-2

K Lenart - 2024 - openarchive.ki.se
The emergence of a novel coronavirus, SARS-CoV-2, sparked a global health crisis, leading
to the COVID-19 pandemic. Development and deployment of vaccines against COVID-19 …

[引用][C] Sphingolipids as modulators of T cell function

PC de Casas - 2024 - School of Life Sciences, Julius …