Autophagy is a core molecular pathway for the preservation of cellular and organismal
homeostasis. Pharmacological and genetic interventions impairing autophagy responses …

The term autophagy encompasses different pathways that route cytoplasmic material to
lysosomes for degradation and includes macroautophagy, chaperone-mediated autophagy …

Alzheimer's disease and related dementias (ADRD) are among the top contributors to
disability and mortality in later life. As with many chronic conditions, aging is the single most …

Aging of the brain can manifest itself as a memory and cognitive decline, which has been
shown to frequently coincide with changes in the structural plasticity of dendritic spines …

Autophagy, an essential cellular process that mediates degradation of proteins and
organelles in lysosomes, has been tightly linked to cellular quality control for its role as part …

Macroautophagy is an evolutionarily conserved process that delivers diverse cellular
contents to lysosomes for degradation. As our understanding of this pathway grows, so does …

Alzheimer's disease (AD) is a complex neurodegenerative disease in the elderly and the
most common cause of human dementia. AD is characterized by accumulation of abnormal …

Decreased cognitive performance is a hallmark of brain aging, but the underlying
mechanisms and potential therapeutic avenues remain poorly understood. Recent studies …

Autophagy is the major cellular pathway to degrade dysfunctional organelles and protein
aggregates. Autophagy is particularly important in neurons, which are terminally …

Alzheimer disease (AD) is biologically defined by the presence of β-amyloid-containing
plaques and tau-containing neurofibrillary tangles. AD is a genetic and sporadic …