Research over the past decade has extended the prevailing view of the mitochondrion to
include functions well beyond the generation of cellular energy. It is now recognized that …

The field of mitochondrial ion channels has recently seen substantial progress, including the
molecular identification of some of the channels. An integrative approach using genetics …

Apoptosis-inducing factor (AIF) is a flavin adenine dinucleotide-containing, NADH-
dependent oxidoreductase residing in the mitochondrial intermembrane space whose …

VDAC1 is found at the crossroads of metabolic and survival pathways. VDAC1 controls
metabolic cross-talk between mitochondria and the rest of the cell by allowing the influx and …

Mutations in superoxide dismutase (SOD1) cause amyotrophic lateral sclerosis (ALS), a
neurodegenerative disease characterized by loss of motor neurons. With conformation …

Reactive oxygen species (ROS) modulate sphingolipid metabolism, including enzymes that
generate ceramide and sphingosine-1-phosphate (S1P), and a ROS-antioxidant rheostat …

Background It was well known that the clinical use of chemotherapeutic drugs is restricted by
severe adverse reactions and drug resistances. Thus it is necessary to figure out a strategy …

Mitochondria are the respiratory and energetic centers of the cell where multiple intra-and
extracellular signal transduction pathways converge leading to dysfunction of those …

Previous studies have implicated that hypoxic stress could enhance osteoclast
differentiation; however, the underlying mechanism remains poorly understood. Autophagy …

Apoptosis is thought to play a critical role in several pathological processes, such as
neurodegenerative diseases (ie Parkinson's and Alzheimer's diseases) and various …